2005.9-2009.7 中国药科大学，学士

2009.9-2012.8 中国科学院上海药物研究所，硕士

2012.9-2013.7 清华大学，科研助理

2013.9-2018.7 美国科罗拉多大学博尔德分校，博士

2018.11-2013.4 耶鲁大学，博士后

2023.5-至今  中国科学院上海有机化学研究所生物与化学交叉研究中心，研究员，课题组长

通过发展和运用化学生物学的手段来研究和干预免疫系统和神经系统的疾病发生发展过程，并基于新型的双功能分子（例如PROTAC和PhosTAC等），进行新型药物的开发。重点研究导致自身免疫系统的过度激活，以及神经退行疾病中的致病蛋白，并开发相关的抑制剂药物进行疾病治疗的探索。

1. Zhenyi Hu^#; Po-Han Chen^#; Wenxue Li; Todd Douglas; John Hines; Yansheng Liu; Craig M. Crews. Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality, Journal of the American Chemical Society, 2023, 145(7): 4045-4055

2. Hu, Z.^#; Chen, P. H.^#; Li, W.^#; Krone, M.; Zheng, S.; Saarbach, J.; Velasco, I. U.; Hines, J.; Liu, Y.; Crews, C. M. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Science Advances 2024, 10 (13), eadj725

3. Shuting Zhang^#; Zhenyi Hu^#; Hiromi Tanji^#; Shuangshuang Jiang; Nabanita Das; Jing Li; Kentaro Sakaniwa; Jin Jin; Yanyan Bian; Umeharu Ohto; Toshiyuki Shimizu; Hang Yin. Small-molecule inhibition of TLR8 through stabilization of its resting state, Nature Chemical Biology, 2018, 14(1): 58-64

4. Zhenyi Hu; Hiromi Tanji; Shuangshuang Jiang; Shuting Zhang; Kyoin Koo; Jean Chan; Kentaro Sakaniwa; Umeharu Ohto; Albert Candia; Toshiyuki Shimizu; Hang Yin. Small-molecule TLR8 antagonists via structure-based rational design, Cell Chemical Biology, 2018, 25(10): 1286-1291

5. Po-Han Chen^#; Zhenyi Hu^#; Elvira An; Ifunanya Okeke; Sijin Zheng; Xuanmeng Luo; Angela Gong; Saul Jaime-Figueroa; Craig M. Crews ; Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs), ACS Chemical Biology, 2021, 16(12): 2808-2815

6. Zhenyi Hu; Craig M Crews ; Recent developments in PROTAC-mediated protein degradation: from bench to clinic., Chembiochem : a European journal of chemical biology, 2021, 23(2): e2021002