复杂天然产物的化学合成；天然产物的作用机制解析

2022  China Youth Science and Technology Award

2022  Chinese Chemical Society−Royal Society of Chemistry Young Chemist Award

2020  XPLORER Prize

2020  Thieme−IUPAC Prize in Synthetic Organic Chemistry

2019  Fellow, Royal Society of Chemistry

2017  Tetrahedron Young Investigator Award for Organic Synthesis

2016  Chinese−American Chemistry and Chemical Biology Professors Association Distinguished Faculty Award

2016  ChemComm Emerging Investigator Lectureship

2015  WuXi PharmaTech Life Science and Chemistry Award

2013  Chinese Chemical Society Wei-Shan Award for Natural Product Synthesis

2013  China Pharmaceutical Association−Servier Youth Medicinal Chemist Award

2007  Chinese Government Award for Outstanding Graduate Students Abroad

2007  Bristol−Myers Squibb Graduate Fellowship

1. L. Ren, Z. Lu, D. Wu, M. Ma, A. Li,* Total synthesis of paxdaphnine A and daphlongamine B via an aza-Prins cyclization strategy. J. Am. Chem. Soc. DOI: 10.1021/jacs.4c04779.

2. Y. Fei, B. Fan, Z. Liu, M. Ba, Z. Cui, P. Yang,* A. Li,* Concise total synthesis of ambiguine P. J. Am. Chem. Soc. 2025, 147, 18391–18396.

3. Y. Wu, S. Wang, Z. Guo, M. Sun, Z. Xu, Y. Du, F. Zhu, Y. Su, Z. Xu, Y. Xu, X. Gong, R. Fang, J. Hu, Y. Peng, Z. Ding, C. Liu, A. Li,* W. He,* Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy, Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2400809121.

4. M. Ba, F. He, L. Ren, W. G. Whittingham, P. Yang, A. Li,* Scalable total synthesis of acremolactone B, Angew. Chem. Int. Ed. 2024, 63, e202314800.

5. Y. Peng, Y. Zhang, R. Fang, H. Jiang, G. Lan, Z. Xu, Y. Liu, Z. Nie, L. Ren, F. Wang, S.-D. Zhang, Y. Ma, P. Yang, H.-H. Ge, W.-D. Zhang,* C. Luo,* A. Li,* W. He,* Target identification and mechanistic characterization of indole terpenoid mimics: proper spindle microtubule assembly is essential for Cdh1-mediated proteolysis of CENP-A, Adv. Sci. 2024, 11, 2305593.

6. W. Zhang, M. Lu, L. Ren, X. Zhang, S. Liu, M. Ba, P. Yang, A. Li,* Total synthesis of four classes of Daphniphyllum alkaloids, J. Am. Chem. Soc. 2023, 145, 26569–26579.

7. B.-C. Yan, M. Zhou, J. Li, X.-N. Li, S.-J. He, J.-P. Zuo, H.-D. Sun, A. Li,* P.-T. Puno,* (–)-Isoscopariusin A, a naturally occurring immunosuppressive meroditerpenoid: structure elucidation and scalable chemical synthesis. Angew. Chem. Int. Ed. 2021, 60, 12859–12867.

8. P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,* A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 2020, 142, 13701–13708.

9. S. Zhou, K. Xia, X. Leng, A. Li,* Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc. 2019, 141, 13718–13723.

10. X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed. 2019, 58, 6053–6058.

11. Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc. 2018, 140, 9211–9218.

12. S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc. 2018, 140, 9025–9029.

13. W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 2018, 140, 4227–4231.

14. Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 2018, 57, 952–956.

15. J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc. 2017, 139, 14893‒14896.

16. Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 2017, 139, 5558–5567.

17. H. Li, Q. Chen, Z. Lu, A. Li,* Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc. 2016, 138, 15555–15558.

18. P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 2016, 55, 6964–6968.

19. Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 2016, 138, 3982–3985.

20. M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole. Angew. Chem. Int. Ed. 2016, 55, 2851–2855.

21. Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc. 2015, 137, 13764–13767.

22. S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,* Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed. 2015, 54, 6878–6882.

23. M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun. 2015, 6, 6445.

24. Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun. 2015, 6, 6096.

25. J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 2014, 136, 16477–16480.

26. Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed. 2014, 53, 13840–13844.

27. Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed. 2014, 53, 9012–9016.

28. J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 2014, 136, 8185–8188.

29. Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed. 2013, 52, 9201–9204.

30. Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum alkaloid daphenylline. Nat. Chem. 2013, 5, 679–684.

31. M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc. 2012, 134, 8078–8081.

32. J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 2012, 134, 920–923.