教育经历:
2006-2010 吉林大学 学士学位
2010-2015 清华大学 博士学位
工作经历
2016-2021 OHSU/HHMI 博士后
2021.12 -至今 中国科学院有机化学研究所 研究员、课题组组长
1. Yu J*, Rao P*, Clark S, Mitra J, Ha T and Gouaux E. Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition (2021). Nature, 594(7863):448-453.
2. Yu J*, Zhu H*, Lape R, Greiner T, Du J, Lü W, Sivilotti L, Gouaux E. Mechanism of gating and partial agonist action in the glycine receptor (2021). Cell, 184:957-968.e21.
3. Phulera S*, Zhu H*, Yu J*, Claxton DP, Yoder N, Craig Yoshioka C, Gouaux E. Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA (2018). eLife, 7:e39383.
4. Yu J.*, Zhang B, Zhang Y, Xu CQ, Zhuo W, Ge J, Li J, Gao N, Li Y, Yang M. A binding-block ion selective mechanism revealed by a Na/K selective channel (2018). Protein Cell, 9(7):629-639.
5. Yu J*, Ge J*., Heuveling J, Schneider E, and Yang M. Structural basis for substrate specificity of an amino acid ABC transporter (2015). Proc Natl Acad Sci USA, 112, 5243-5248.
6. Yu J*, Pian Y*, Ge J*, Guo J, Zheng Y, Jiang H, Hao H, Yuan Y, Jiang Y, and Yang M. Functional and structural characterization of the antiphagocytic properties of a novel transglutaminase from streptococcus suis (2015). J. Bio. Chem, 290, 19081-19092.
7. Ivica J, Lape R, Jazbec V, Yu J, Zhu H, Gouaux E, Sivilotti LG. The intracellular domain of homomeric glycine receptors modulates agonist efficacy (2021). J. Bio. Chem, 296, 100387.
8. Yang Y, Yu Y, Li X, Li J, Wu Y, Yu J, Ge J, Huang Z, Jiang L, Rao Y, Yang M. Target elucidation by cocrystal structures of NADH-Ubiquinone oxidoreductase of Plasmodium falciparum (PfNDH2) with small molecule to eliminate drug-resistant malaria (2017). J. Med. Chem, 60(5):1994-2005.
9. Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y, Yang M. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance (2012). Proc Natl Acad Sci USA, 109, 18180-18185.