2012.8-2017.12 新加坡国立大学力学生物学研究所,博士
2009.8-2012.6 东南大学生物医学工程专业,硕士
2005.8-2009.6 东南大学生物医学工程专业,学士
工作经历
2022.2-至今 中国科学院生物与化学交叉研究中心,研究员、课题组长
2019.9-2022.1 复旦大学复杂体系多尺度研究院,青年研究员
2018.2-2019.9 加州大学伯克利分校化学系,博士后
1)体外模拟脂质双层膜系统的开发和应用;
2)免疫和神经系统中细胞间相互识别和信号转导的分子机制;
3)细胞膜黏附受体的机械力-化学信号调控机制。1. Chen, Z. #; Oh, D. #; Biswas, K. H.; Zaidel-Bar, R.; Groves, J. T., Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. eLife 2021, 10, e67379.
2. Chen, Z. #; Cao, Y. #; Lin, C.-W.; Alvarez, S.; Oh, D.; Yang, P.; Groves, J. T., Nanopore-mediated protein delivery enabling three-color single-molecule tracking in living cells. PNAS 2021, 118 (5), e2012229118.
3. Wong, J. J. #; Chen, Z. #; Chung, J. K.; Groves, J. T.; Jardetzky, T. S., EphrinB2 clustering by Nipah virus G is required to activate and trap F intermediates at supported lipid bilayer-cell interfaces. Science Advances 2021, 7 (5), eabe1235.
4. Chen, Z. #; Oh, D. #; Biswas, K. H.; Yu, C.-H.; Zaidel-Bar, R.; Groves, J. T., Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility. PNAS 2018, 115:e5696.
5. Chen, Z. #; Oh, D. #; Dubey, A. K. #; Yao, M. #; Yang, B. #; Groves, J. T.; Sheetz, M., EGFR family and Src family kinase interactions: mechanics matters? Current Opinion in Cell Biology 2018, 51, 97-102.
6. Chen, Z.; Yin, J.-J.; Zhou, Y.-T.; Zhang, Y.; Song, L.; Song, M.; Hu, S.; Gu, N., Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity. ACS Nano 2012, 6 (5), 4001-4012.