研究血管在衰老和疾病过程中的功能改变。将综合应用下一代测序技术，高分辨率显微成像技术，并制备新的动物模型用以研究以下问题： 

　　1. 血管新生过程中，不同血管内皮细胞群体的特性。并筛选新一代特异性的抑制肿瘤血管新生的药物。 

　　2. 神经退行性疾病过程中，血管功能的改变，并探索基于改善血管内皮细胞功能的治疗方法。 

　　Hu J*, Srivastava K*, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science, 343: 416-419, 2014 (* equal contribution)  

    Korn C*, Scholz B*, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I: Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development, 141: 1757-1766, 2014. (* equal contribution). 

　  Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Gerauld C, Arnold B, Rohr K, Komljenovic, D., Schirmacher P, Goerdt S, Augustin HG: An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice. Cancer Research, 74: 4157-4169, 2014. 

　　Srivastava K*, Hu J*, Korn C, Kapel S, Jugold M, Besemfelder E, Thomas M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy effectively limits metastatic progression. Cancer Cell, 26: 880-895, 2014 (* equal contribution). 

　　Mogler C*, Wieland M*, K？nig C, Hu J, Runge A, Korn K, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley Steven, Schirmacher P, Longerich T, Augustin HG: Hepatic Stellate cell expressed Endosialin balances fibrogenesis and hepatocyte proliferation during liver damage. Embo Mol Med, 7: 332-228， 2015,  

　　Yang WJ*, Hu J*, Uemura A, Tetzlaff F, Augustin HG, Fischer A: Semaphorin-3C signals through Neuropilin-1 and Plexin-D1 receptors to inhibit pathological angiogenesis. Embo Mol Med, 2015, (in press) (* equal contribution)