2015.09-present: IRCBC, SIOC, CAS

2011-2015: Postdoc, JHU

2010: Postdoc, UMD

2004-2009: Ph.D. in Neuroscience, UMD

1999-2003: B.S. in Biological Science, Tsinghua Universitiy

神经功能调控与神经退行性疾病早期发病机制。

神经细胞是大脑的功能单位，它们的正常调控是维持所有高等认知功能，如感知、学习与记忆储存等的生理基础；而异常调控则会直接造成神经功能障碍，是各类神经系统疾病，尤其是退行性疾病的主要原因。因此，深入研究神经功能的调控机制是认识大脑运作的关键，同时也是了解神经系统疾病发病机制、促进疾病预防和治疗的重要手段。

神经功能受到很多因素调控，其中我们最感兴趣的是睡眠在其中发挥的作用。睡眠作为普遍存在于生物界的一个保守的生理现象，对维持生物机体功能包括脑功能至关重要。然而，目前我们对睡眠如何调控神经功能了解得非常有限。另外，神经系统疾病如退行性疾病患者大都患有不同程度不同类型的睡眠障碍，且睡眠障碍通常远早于脑疾病其他病症出现，说明睡眠与脑疾病有非常密切的联系。因此，我们实验室研究的主要问题包括：1）正常生理状态下，睡眠对神经功能如神经信号传导、神经可塑性、神经网络稳态等的调控作用和调控机制；2）睡眠障碍与神经退行性疾病的相互关系；3）神经退行性疾病的早期发病机制研究。我们将综合运用体内外电生理和显微成像、光遗传、药物学、细胞生物学、和行为学分析等多种手段，来研究以上问题。

1. X-R Yao, Y Liu, W-T Zheng, K-W He*. Behavior- and circuit-specific cortico-striatal decoupling during the early development of Parkinson's disease-like syndrome. bioRxiv 2024.08.13.607859 (Under revision in npj Parkinson's Disease)

2. Zhu J, Yang W, Ma J, He H, Liu Z, Zhu X, He X, He J, Chen Z, Jin X, Wang X, He K, Wei W, Hu J. Pericyte signaling via soluble guanylate cyclase shapes the vascular niche and microenvironment of tumors. EMBO J. 2024 Mar 25. doi: 10.1038/s44318-024-00078-5. Epub ahead of print. PMID: 38528180

3. Cao Z, Min X, Xie X, Huang M, Liu Y, Sun W, Xu G, He M, He K^#, Li Y, Yuan J^#. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. PNAS. 2024 Feb 6;121(6): e2320383121. doi: 10.1073/pnas.2320383121. Epub 2024 Jan 30. PubMed PMID: 38289948.

4. Guo R., Liu J., Min X., Zeng W., Shan B., Zhang M., He Z., Zhang Y., He K., Yuan J., Xu D.^#. Reduction of DHHC5-mediated Beclin 1 S-palmitoylation underlies autophagy decline in aging. Nat Struct Mol Biol. 2024 Jan 4; doi: 10.1038/s41594-023-01163-9. PubMed PMID: 38177673.

5. Min X, Wang JY, Zong FJ, Zhao J, Liu N, He KW^#. miR-34a regulates silent synapse and synaptic plasticity in mature hippocampus. Prog Neurobiol. 2023 Jan 13;222:102404. doi: 10.1016/j.pneurobio.2023.102404.

6. Zong FJ, Min X, Zhang Y, Li YK, Zhang XT, Liu Y, He KW^#. Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons. EMBO J. 2023 Feb 1;42(3):e111304. doi: 10.15252/embj.2022111304. Epub 2022 Dec 7. PMID: 36477886; PMCID: PMC9890233.

7. Wang JY, Ma GM, Tang XQ, Shi QL, Yu MC, Lou MM, He KW^#, Wang WY^#. Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition. Brain. 2023 May 2;146(5):2107-2119. doi: 10.1093/brain/awac411. PubMed PMID: 36345573

8. T Li, Y Yin, Z Zhou, J Qiu, W Liu, X Zhang, K He, Y Cai, ZJ Zhu^# (2021) Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain, Nature Communications 12 (1), 1-13

9. S Mihalas, A Ardiles, K He, A Palacios, A Kirkwood^# (2021) A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity, Frontiers in Synaptic Neuroscience, 38

10. Long H*, Zheng W*, Liu Y, Sun Y, Zhao K, Liu Z, Xia W, Lv S, Liu Z, Li D, He KW^#, Liu C^# (2021) Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. PNAS, 118(20):e2012435118. doi: 10.1073/pnas.2012435118. PMID: 33972418.

11. M Bridi*, F-J Zong*, X Min N Luo, T Tran, J Qiu, D Severin, X-T Zhang, G Wang, Z-J Zhu, K-W He^#, A Kirkwood^# (2020) Daily Oscillations in the Excitation-Inhibition Balance in Visual Cortical Circuits, Neuron, 105(4):621-629.e4. doi: 10.1016/j.neuron.2019.11.011

12. Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A^# (2018) Two distinct mechanisms for experience-dependent homeostasis. Nat Neurosci. 21(6):843-850

13. He K, Huertas M, Hong S, Tie X, Hell J.W, Shouval H, Kirkwood A^# (2015) Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron, 88(3): 528-38

14. Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, Lee HK, Hen R, Xu X, Sahay A^# (2013) Adult neurogenesis modulates excitability of the dentate gyrus. Frontiers in Neural Circuits. 7:204

15. Wang H*, Megill A*, He K, Kirkwood A, Lee HK^# (2012) Consequences of inhibiting amyloid precursor protein (APP) processing enzymes on synaptic function and plasticity. Neural Plasticity. 2012:272374

16. He K, Petrus E, Gammon N, Lee HK^#, (2012) Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. Journal of Neuroscience. 32(25):8469-74

17. Huang S*, Treviño M*, He K*, Ardiles A, Pasquale R, Guo Y, Palacios A, Huganir R, Kirkwood A^# (2012) Pull-push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510 (Recommended by F1000Prime)

18.  Qian H, Matt L, Zhang M, Nguyen M, Patriarchi T, Koval OM, Anderson ME, He K, Lee HK, Hell JW^# (2012) The β2 Adrenergic Receptor Supports Prolonged Theta Tetanus - induced LTP. J Neurophysiol.

19. He K, Goel A, Ciarkowski CE, Song L, Lee HK^# (2011) Brain area specific regulation of synaptic AMPA receptors by phosphorylation. Commun Integr Biol. 4(5):569-72

20. He K, Lee A, Song L, Kanold PO, Lee HK^# (2011) AMPA receptor subunit GluR1 (GluA1) serine-845 site is involved in synaptic depression but not in spine shrinkage associated with chemical long-term depression. Journal of Neurophysiology. 105(4):1897-907

21. Lee HK, Takamiya K, He K, Song L, Huganir RL^# (2010) Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. Journal of Neurophysiology. 103(1):479-89

22. He K, Song L, Cummings LW, Goldman J, Huganir RL, Lee HK^# (2009) Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. PNAS, 106(47):20033-8(Recommended by F1000Prime)

23. Lee HK, Takamiya K, Kameyama K, He K, Yu S, Rossetti L, Wilen D, and Huganir RL ^# (2007) Idenfication and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neuroscience, 36(1):86-94.

24. Laird FM*, Cai H*, Savonenko AV*, Farah MH*, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC^# (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid- amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. Journal of Neuroscience, 25(50):11693-11709.

* Equally contributing authors.^# Corresponding author