2000.09—2004.06 南开大学化学学院本科
2004.09—2007.06 南开大学化学学院硕士研究生
2007.10—2010.09 日本东京大学药学部博士 (Prof. Masakatsu Shibasaki and Prof. Motomu Kanai)
2010.10—2011.03 日本东京大学药学部JSPS博士后 (Prof. Motomu Kanai)
2011.04—2012.03 美国哈佛大学化学与化学生物学系博士后 (Prof. E. J. Corey)
2012.04—2014.10 日本微生物化学研究所JSPS外国人博士后 (Prof. Masakatsu Shibasaki)
2014.10—至今 中国科学院上海有机化学研究所研究员、课题组长
1. 手性含氟/氮功能分子的创制与应用
2. 含能分子的创制与应用
3. 不对称催化
2014年 中国科学院人才项目
2015年 上海市“青年科技启明星计划”
2015年 国家青年人才项目
2015年 上海市“青年科技启明星计划”
2017年 Thieme Chemistry Journals Award
2019年 基金委“优秀青年科学基金”
2019年 中国科学院“优秀导师奖”
2019年 入选“中国青年化学家元素周期表”代言铜元素
2019年 中国科学院人才项目终期评估优秀
2021年 上海市“优秀学术带头人计划”
2023年 上海市科技系统“青年五四奖章
1. J.-Z. Xiao, Z.-X. Cai, Z.-Z. Pan, Y. Wang, N. Jiang, L. Yin*. Copper(I)-Catalyzed Asymmetric 1,4-Hydroarsination of α,β-Unsaturated Compounds. Angew. Chem. Int. Ed. 2025, 64, e202413834.
2. Z.-C. Liu, H.-M. Zhang, Y. Li, Z.-Q. Wang, L. Yin*. Copper(I)-Catalyzed Enantioselective α-Alkylation of 2-Acylimidazoles. J. Am. Chem. Soc. 2024, 146, 34265–34273.
3. N. Jiang, P.-Z. Liu, Z.-Z. Pan, S.-Q. Wang, Q. Peng*, L. Yin*. Asymmetric Synthesis of Trisubstituted Vicinal Diols through Copper(I)-Catalyzed Diastereoselective and Enantioselective Allylation of Ketones with Siloxypropadienes. Angew. Chem. Int. Ed. 2024, 63, e202402195.
4. Z.-Z. Pan, J.-H. Li, H. Tian, L. Yin*. Copper(I)-Catalyzed Asymmetric Allylation of Ketones with 2-Aza-1,4-Dienes. Angew. Chem. Int. Ed. 2024, 63, e202315293.
5. S. Zhang, N. Jiang, J.-Z. Xiao, G.-Q. Lin, L. Yin*. Copper(I)-Catalyzed Asymmetric Hydrophosphination of 3,3-Disubstituted Cyclopropenes. Angew. Chem. Int. Ed. 2023, 62, e202218798.
6. H. Tian, H.-M. Zhang, L. Yin*. Copper(I)-Catalyzed Conjugate Addition/Enantioselective Protonation with Selenols and α-Substituted α,β-Unsaturated Thioamides. Angew. Chem. Int. Ed. 2023, 62, e202301422.
7. Z.-Z. Pan, D. Pan, J.-H. Li, X.-S. Xue*, L. Yin*. Copper(I)-Catalyzed Asymmetric Conjugate Addition of 1,4-Dienes to β‑Substituted Alkenyl Azaarenes. J. Am. Chem. Soc. 2023, 145, 1749–1758.
8. B.-R. Wang, Y.-B. Li, Q. Zhang, D. Gao, P. Tian* Q. Li*, L. Yin*. Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides. Nat. Commun. 2023, 14, 4688.
9. Z.-C. Liu, Z.-Q. Wang, X. Zhang, L. Yin*. Copper(I)-catalyzed asymmetric alkylation of α-imino-esters. Nat. Commun. 2023, 14, 2187.
10. Y.-B. Li, H. Tian, S. Zhang, J.-Z. Xiao, L. Yin*. Copper(I)-Catalyzed Asymmetric Synthesis of P-Chiral Aminophosphinites. Angew. Chem. Int. Ed. 2022, e202117760.
11. S. Zhang, J.-Z. Xiao, Y.-B. Li, C.-Y. Shi, L. Yin*. Copper(I)-Catalyzed Asymmetric Alkylation of Unsymmetrical Secondary Phosphines. J. Am. Chem. Soc. 2021, 143, 9912−9921.
12. F. Zhong, Z.-Z. Pan, S.-W. Zhou, H.-J. Zhang, L. Yin*. Copper(I)-Catalyzed Regioselective Asymmetric Addition of 1,4-Pentadiene to Ketones. J. Am. Chem. Soc. 2021, 143, 4556−4562.
13. Q. Zhang, S.W. Zhou, C.-Y. Shi, L. Yin*. Catalytic Asymmetric Allylic Substitution with Copper(I) Homoenolates Generated from Cyclopropanols. Angew. Chem. Int. Ed. 2021, 60, 26351–26356.
14. C.-Y. Shi, J. Eun, T. R. Newhouse*, L. Yin*. Copper(I)-Catalyzed Asymmetric Conjugate 1,6-, 1,8-, and 1,10-Borylation. Angew. Chem. Int. Ed. 2021, 60, 9493–9499.
15. S.-Q. Wang, Z.-C. Liu, W.-J. Yue, L. Yin*. Copper(I)-Catalyzed Asymmetric Vinylogous Aldol-Type Reaction of Allylazaarenes. Angew. Chem. Int. Ed. 2021, 60, 4604–4608.
16. Y.-B. Li, H. Tian, L. Yin*. Copper(I)-Catalyzed Asymmetric 1,4-Conjugate Hydrophosphination of α,β-Unsaturated Amides. J. Am. Chem. Soc. 2020, 142, 20098−20106.
17. W.-J. Yue, J.-Z. Xiao, S. Zhang, L. Yin*. Rapid Synthesis of Chiral 1,2-Bisphosphine Derivatives through Copper(I)-Catalyzed Asymmetric Conjugate Hydrophosphination. Angew. Chem. Int. Ed. 2020, 59, 7057–7062.
18. F. Zhong, Q.-Y. Xue, L. Yin*. Construction of Chiral 2,3-Allenols through a Copper(I)-Catalyzed Asymmetric Direct Alkynylogous Aldol Reaction. Angew. Chem. Int. Ed. 2020, 59, 1562–1566.
19. C.-Y. Shi, Z.-Z. Pan, P. Tian*, L. Yin*. Copper(I)-catalyzed asymmetric 1,6-conjugate allylation. Nat. Commun. 2020, 11, 5480.
20. X.-C. Gan, C.-Y. Zhang, F. Zhong, P. Tian*, L. Yin*. Synthesis of chiral anti-1,2-diamine derivatives through copper(I)-catalyzed asymmetric α-addition of ketimines to aldimines. Nat. Commun. 2020, 11, 4473.
21. H.-J. Zhang, Y.-C. Xie. L. Yin*. Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines. Nat. Commun. 2019, 10, 1699.
22. F. Zhong, W.-J. Yue, H.-J. Zhang, C.-Y. Zhang, L. Yin*. Catalytic Asymmetric Construction of Halogenated Stereogenic Carbon Centers by Direct Vinylogous Mannich-Type Reaction. J. Am. Chem. Soc. 2018, 140, 15170−15175.
23. H.-J. Zhang, L. Yin*. Asymmetric Synthesis of α,β-Unsaturated δ‑Lactones through Copper(I)-Catalyzed Direct Vinylogous Aldol Reaction. J. Am. Chem. Soc. 2018, 140, 12270−12279.
24. H.-J. Zhang, A. W. Schuppe, S.-T. Pan, J.-X. Chen, B.-R. Wang, T. R. Newhouse*, L. Yin*. Copper-Catalyzed Vinylogous Aerobic Oxidation of Unsaturated Compounds with Air. J. Am. Chem. Soc. 2018, 140, 5300−5310.
25. H.-J. Zhang, C.-Y. Shi, F. Zhong, L. Yin*. Direct Asymmetric Vinylogous and Bisvinylogous Mannich-Type Reaction Catalyzed by a Copper(I) Complex. J. Am. Chem. Soc. 2017, 139, 2196−2199.
