杰出青年
施世良
职  称: 研究员
学  历: 博士研究生
电  话: 021-54925580
职  务: 课题组长
传  真: 021-64166128
电子邮件: shiliangshi@sioc.ac.cn
个人网页:
通信地址: 上海市零陵路345号
个人简历

2016.06-至今    中国科学院上海有机化学研究所金属有机化学国家重点实验室, 研究员

2012.11-2016.05   麻省理工学院化学系,博士后研究员(导师: Prof. Stephen L. Buchwald

2011.10-2012.10   东京大学药学部, JSPS博士后研究员(导师: Prof. Motomu Kanai

2008.10-2011.09   东京大学药学部, 博士(导师:Prof. Masakatsu Shibasaki and Prof. Motomu Kanai

研究方向

发展新型优势手性配体;发展新型高效的不对称催化反应;发展经济、绿色和高效的手性药物及药物中间体合成新工艺。

社会任职
获奖及荣誉

2023 国家杰出青年科学基金获得者

2022 上海市优秀学术带头人

2021  Bayer Investigator Award

2019  Thieme Chemistry Journals Award

2016 国家海外高层次人才计划

2016 中科院人才计划

代表论著

1.Lin-Xin Ruan, Bo Sun, Jia-Ming Liu, Shi-Liang Shi*Dynamic kinetic asymmetricarylation and alkenylation of ketones. Science 2023, 379, 662?670.

2.Zi-Chao Wang#, Xiaohua Luo#, Jia-Wen Zhang#, Chen-Fei Liu#, Ming Joo Koh*, Shi-Liang Shi* Enantioselective C–C cross-coupling of unactivated alkenes. Nat. Catal. 2023, 6, 1087–1097.

3.Zi-Chao Wang, Jia-Wen Zhang, Ming Joo Koh*, Shi-Liang Shi* Divergent and Selective Light Alkene Cross-Coupling. Angew. Chem. Int. Ed., 2023, 62, e202310203.

4.Binyang Jiang, Jia-ming Liu, Shi-Liang Shi* Bifunctional NHC-Promoted C2-Alkylation of Pyridine via Ni–Al Bimetallic-Catalyzed Hydroarylation of Unactivated Alkenes. ACS Catal. 2023, 13, 6068-6075.

5.Zi-Chao Wang, Yan-Yu Li, Shuo-Qing Zhang, Xin Hong*, Shi-Liang Shi* Unsymmetric N-heterocyclic carbene ligand enabled nickel-catalysed arylation of bulky primary and secondary amines. Chem. Sci., 2023, 14, 4390-4396.

6.Chen-Fei Liu#, Zi-Chao Wang#, Xiaohua Luo#, Jiawei Lu, Charyl Hui Min Ko, Shi-Liang Shi*, Ming Joo Koh* Synthesis of tri- and tetrasubstituted stereocentres by nickel-catalysed enantioselective olefin cross-couplings. Nat. Catal. 2022, 5, 934-942.

7.Jun-Bao Ma, Xia Zhao, Dongju Zhang*, Shi-Liang Shi* Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation. J. Am. Chem. Soc. 2022, 144, 13643–13651.

8.Wu-Bin Zhang, Guang Chen, Shi-Liang Shi* Enantioselective Ni/N-Heterocyclic Carbene-Catalyzed Redox-Economical Coupling of Aldehydes, Alkynes, and Enones for Rapid Construction of Acyclic All-Carbon Quaternary Stereocenters. J. Am. Chem. Soc. 2022, 144, 130-136.

9.Zi-Chao Wang, Jian Gao, Yuan Cai, Xiaodong Ye, Shi-Liang Shi* Chemo- and Enantioselective Arylation and Alkenylation of Aldehydes Enabled by Nickel/N-Heterocyclic Carbene Catalysis. CCS Chem. 2022, 4, 1169–1179.

10.Binyang Jiang, Shi-Liang Shi* Pd-Catalyzed Cross-Coupling of Alkylzirconocenes and Aryl Chlorides. Chin. J. Chem. 2022, 40, 1813-1820.

11.Yuan Cai, Shi-Liang Shi* Enantioconvergent Arylation of Racemic Secondary Alcohols to Chiral Tertiary Alcohols Enabled by Nickel/N-Heterocyclic Carbene Catalysis. J. Am. Chem. Soc. 2021, 143, 11963-11968.

12.Zi-Chao Wang, Pei-Pei Xie, Youjun Xu, Xin Hong*, Shi-Liang Shi* Low-Temperature Ni-Catalyzed C-N Cross-Coupling via Kinetic Resolution Enabled by a Bulky yet Flexible Chiral N-Heterocyclic Carbene Ligand. Angew. Chem. Int. Ed. 2021, 60, 16077–16084.

13.   Yuan Cai, Lin-Xin Ruan, Abdul Rahman, Shi-Liang Shi* Fast Enantio- and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel/NHC Catalysis. Angew. Chem., Int. Ed. 2021, 60, 5262–5267.

14.Yu-Qing Li, Feng Li, Shi-Liang Shi* Expedient Synthesis of Ketones via N-Heterocyclic Carbene/Nickel-Catalyzed Redox-Economical Coupling of Alcohols and Alkynes. Chin. J. Chem. 2020, 38, 1035-1039.

15.Wu-Bin Zhang, Xin-Tuo Yang, Jun-Bao Ma, Zhi-Min Su, Shi-Liang Shi* Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis. J. Am. Chem. Soc. 2019, 141, 5628-5634.

16.Di Shen, Youjun Xu, Shi-Liang Shi* A Bulky Chiral N-Heterocyclic Carbene Palladium Catalyst Enables Highly Enantioselective Suzuki-Miyaura Cross-Coupling Reactions for the Synthesis of Biaryl Atropisomers. J. Am. Chem. Soc. 2019, 141, 14938-14945.

17.Yuan Cai, Xiaodong Ye, Sheng Liu, Shi-Liang Shi* Nickel/NHC-Catalyzed Asymmetric C–H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins. Angew. Chem. Int. Ed. 2019, 58, 13433-13437.

18.Yuan Cai, Jia-Wen Zhang, Feng Li, Jia-Ming Liu, Shi-Liang Shi* Nickel/N-Heterocyclic Carbene Complex-Catalyzed Enantioselective Redox-Neutral Coupling of Benzyl Alcohols and Alkynes to Allylic Alcohols. ACS Catal. 2019, 9, 1-6.

19.Yuan Cai, Xin-Tuo Yang, Shuo-Qin Zhang, Feng Li, Yu-Qin Li, Lin-Xin Ruan, Xin Hong*, Shi-Liang Shi* Copper-Catalyzed Enantioselective Markovnikov Protoboration of a-Olefins Enabled by a Buttressed N-Heterocyclic Carbene Ligand. Angew. Chem. Int. Ed. 2018, 57, 1376-1380. 

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