2001年9月~ 2005年7月，复旦大学化学系，获理学学士学位。
2005年9月~ 2010年6月，香港科技大学生物化学系，获哲学博士学位。
2010年8月~ 2011年2月，香港科技大学生命科学部，助理研究员。
2011年3月~ 2012年8月，香港科技大学生命科学部，研究助理教授。
2013年1月~ 2013年4月，美国哈佛大学医学院，访问学者。
2012年8月~至今，中国科学院上海有机化学研究所，研究员、课题组长。
1.以人类疾病为导向，综合利用结构生物学、化学生物学、生物化学等多手段的交叉学科研究，具体包括：研究与癌症、神经退行性疾病相关的细胞自噬通路，揭示相关未知的分子机制和致病机理；研究与疾病相关的重要E3泛素酶的结构与作用机制，并研发相关的小分子调节剂和靶向降解技术，用于后续相关的化学生物学和潜在的疾病治疗研究。
2.活性小分子的化学生物学研究，具体包括：天然活性小分子与靶点蛋白相互作用的机制研究；重要生物合成酶与小分子的互作机制以及相关的催化反应机理研究。
2021：中国科学院朱李月华优秀教师奖；
2020：上海市青年五四奖章个人；上海市优秀学术带头人。
2019：上海市科技系统青年五四奖章。
2017：中国化学会青年化学奖。
2013：上海市科技启明星计划。
2011：第四届亚太核磁共振会议青年科学家旅行资助奖（口头报告）。
2010：香港科学会年度生命科学领域青年科学家奖，决赛选手；香港科技大学生命科学部研究生
科研奖；香港大学间生物化学研究生学术研讨会，平台报告奖。
2009：香港科技大学生物化学系研究生科研成就奖；第三届亚太核磁共振会议青年科学家旅行资
助奖。
2005：上海市优秀本科毕业生；复旦大学人民一等奖学金。
2004：复旦大学联合利华一等奖学金；复旦大学优秀学生干部。
1. Zhang Y, Sun Y, Shi J, Xu P, Wang Y, Liu J, Gong X, Wang Y, Tang Y, Liu H, Zhou X, Lin Z, Baba O, Morita T, Yu B*, Pan L* "Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1" PNAS. 2024, 121(37):e2402817121.
2. Zhang M, Wang Y, Gong X, Wang Y, Zhang Y, Tang Y, Zhou X, Liu H, Huang Y, Zhang J, Pan L* "Mechanistic insights into the interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins" PNAS. 2024, 121(11):e2315550121.
3. Xu X, Wang Y, Zhang Y, Wang Y, Yin Y, Peng C, Gong X, Li M, Zhang Y, Zhang M, Tang Y, Zhou X, Liu H, Pan L* "Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain-binding" Science Advances. 2023, 9(41):eadi4599.
4. Zhang T, Xu D, Trefts E, Lv M, Liu J, Liu M, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Jiang C, Dai X, Lee Y, Inuzuka H, Erickson E, Hillis A, Dibble C, Miao J, Asara J, Szabo G, Sicinski P, Pan L*, Shaw R*, Yuan J*, and Wei W* "Metabolic Orchestration of Necroptosis and Inflammation through AMPK-Mediated Phosphorylation of RIPK1" Science. 2023, 380, 1372-1380.
5. Feng K, Zhang Y, Zhang M, Yang Y, Liu J, Pan L*, Zeng Y* "A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone" Nature Communications. 2023, 14(1):3436.
6. Gong X, Pan L* "ATG16L1 is equipped with two distinct WIPI2-binding sites to drive autophagy" Autophagy. 2024, 20(4):938-940.
7. Gong X, Wang Y, Tang Y, Liu J, Wang Y, Xu X, Zhang M, Li M, Zhang Y, Pan L* "ATG16L1 adopts a dual-binding-site mode to interact with WIPI2b in autophagy" Science Advances. 2023, 9(9):eadf0824.
8. Wang H, Zou Y, Li M, Tang Z, Wang J, Tian Z, Strassner N, Yang Q, Zheng Q, Guo Y, Liu W*, Pan L*, and Houk K* "A cyclase that catalyses competing 2+2 and 4+2 cycloadditions" Nature Chemistry. 2023, 15, 177-184.
9. Liu J#*, Wang Y#, Wang D#, Wang Y, Xu X, Zhang Y, Li Y, Zhang M, Gong X, Tang Y, Li M, Pan L* "Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri" PNAS. 2022, 119(12):e2116776119.
10. Fu T, Zhang M, Zhou Z, Wu P, Peng C, Wang Y, Gong X, Li Y, Wang Y, Xu X, Li M, Shen L, Pan L* "Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52" Science Advances. 2021, 7(33):eabi6582.
11. Shan H, Liu J, Shen J, Dai J, Xu G, Lu K, Han C, Wang Y, Xu X, Tong Y, Xiang H, Ai Z, Zhuang G, Hu J, Zhang Z*, Li Y*, Pan L*, Tan L* "Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2" Cell Chemical Biology. 2021, 28, 855-865.
12. Zhou Z, Liu J, Fu T, Wu P, Peng C, Gong X, Wang Y, Zhang M, Li Y, Wang Y, Xu X, Li M, Pan L* "Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation" Nature Communications. 2021, 12(1):1570. (Recommended by Faculty Opinions)
13. Li Y, Cheng Y, Li M, Wang Y, Fu T, Zhou Z, Wang Y, Gong X, Xu X, Liu J, Pan L* "Decoding three distinct states of the Syntaxin17 SNARE motif in mediating the autophagosome-lysosome fusion" PNAS. 2020, 117, 21391-21402. (Recommended by Faculty Opinions)
14. Hu S, Guo Y, Wang Y, Li Y, Fu T, Zhou Z, Wang Y, Liu J, Pan L* "Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering" Nature Communications. 2019, 10(1):3459.
15. Pan L*, Liu J, Li Y, "Structural Basis of Autophagy Regulatory Proteins" Advances in Experimental Medicine and Biology. 2019, 1206:287-326. (invited Book chapter review)
16. Fu T, Liu J, Wang Y, Xie X, Hu S, Pan L* "Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1" PNAS. 2018, 115, E11651-E11660.
17. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zuo C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito M, Meng H, Y Li, Pan H, Aron L, Adiconis X, Levin J, Yankner B, Yuan J.* "TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging" Cell. 2018, 174, 1477-1491.
18. Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L* "Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation" Autophagy. 2018, 14, 66-79.
19. Liu J, Wang Y, Gong Y, Fu T, Hu S, Zhou Z, Pan L* "Structural Insights into SHARPIN-mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly" Cell Reports. 2017, 21(1):27-36.
20. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L*, Yuan J* "USP25 Regulates Wnt Signaling by Controlling the Stability of Tankyrases" Genes. Dev. 2017, 31, 1024-1035.
21. Zhang Z, Gong YK, Zhou Q, Hu Y, Ma HM, Chen YS, Igarashi Y, Pan L*, Tang G* "Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade" PNAS. 2017, 114, 1554-1559.
22. Li F, Xie X, Wang Y, Liu J, Cheng X, Guo Y, Gong Y, Hu S, Pan L* "Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins" Nature Communications. 2016, 7:12708.
23. Cheng X, Wang Y, Gong Y, Li F, Guo Y, Hu S, Liu J, Pan L* "Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins" Autophagy. 2016, 12, 1330-1339.
24. Zheng Q, Guo Y, Yang L, Zhao Z, Wu Z, Zhang H, Liu J, Cheng X, Wu J, Yang H, Jiang H, Pan L*, and Liu W* "Enzyme-Dependent [4+2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4" Cell Chemical Biology. 2016, 23, 352-360.
25. Xie X, Li F, Wang Y, Wang Y, Lin Z, Cheng X, Liu J, Chen C, Pan L* "Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2" Autophagy. 2015, 10, 1775-1789.
26. Pan L, Zhang M.* "Structures of Usher Syndrome 1 Proteins and Their Complexes" Physiology, 2012, 27, 25-42. (invited review, cover story)
27. Wu L#, Pan L#, Wei Z, Zhang M* "Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science. 2011, 331, 757-760. (#:co-first authors, highlighted by Faculty of 1000, F1000 Cell Biology and F1000 Genomics & Genetics)
28. Yan J#, Pan L#, Chen X, Wu L, Zhang M* "The Structure of the Harmonin/Sans Complex Reveals an Unexpected Interaction Mode of the Two Usher Syndrome Proteins" PNAS. 2010,107, 4040-4045. (#: co-first authors)
29. Pan L#, Yan J#, Wu L, Zhang M* "Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23" PNAS. 2009, 106, 5575-5580. (#: co-first authors)
30. Chen J#, Pan L#, Wei Z, Zhao Y, Zhang M* "Domain Swapped Dimerization of ZO-1 PDZ2 Generates Specific and Regulatory Connexin43 Binding Sites" EMBO J, 2008, 27, 2113-2123. (#: co-first authors)
31. Pan L#, Wu H#, Shen C#, Shi Y, Jin W, Xia J, Zhang M* "Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes" EMBO J, 2007, 26, 4576-4587. (#: co-first authors)
