研究员
汤文军
职  称: 研究员
学  历: 博士研究生
电  话: 021-54925515
职  务: 课题组长
传  真: 021-64166128
电子邮件: tangwenjun@sioc.ac.cn
通信地址: 上海市零陵路345号
个人简历

1995年 毕业于华东理工大学精细化工系;

1998年 中国科学院上海有机化学研究所获硕士学位;

2003年 美国宾夕法尼亚州立大学获博士学位;

2003-2005年 美国Scripps研究所从事博士后研究;

2005-2009年 美国Boehringer Ingelheim任高级科学家;

2009-2011年 美国Boehringer Ingelheim任首席科学家;

2011年-至今 中科院上海有机化学研究所研究员、课题组长;同时兼任上海科技大学物质学院教授、博导;杭州高等研究院首席教授;华东理工大学药学院博导。

研究方向

发展新型高效的不对称催化反应;

对具有重要生理活性的复杂天然产物的全合成;

发展高效、经济、绿色的药物新工艺。

社会任职
Green Synthesis & Catalysis;副主编
Organic Process Research & Development;编委
Organic Chemistry Frontier;编委
Chinese Chemical Letter;编委
获奖及荣誉

2024年获英国皇家化学会Organic Division Horizon Prize

2023年中国科学院朱李月华优秀教师奖

2019年入选国家相关人才计划

2019年药明康德生命化学研究奖学者

2018年科技部中青年科技创新领军人才

2017年获国家杰出青年基金资助

2015年获第三届全国均相催化青年奖

2013年入选上海“浦江人才”计划

2012年获Thieme Journal Award

2009年获美国Boehringer Ingelheim 药业公司Presidents Award for Individual Excellence

代表论著

1. “Chiral Polymeric Diamine Ligands for Iridium-Catalyzed Asymmetric Transfer Hydrogenation” Yaodong Lin, Guangqing Xu* Wenjun Tang*. J. Am. Chem. Soc. 2024, just accepted.

2. “Dienediamine: A Safe Herbicide as Paraquat Surrogate” Henian Peng,§ Dake Zhao,§ Wenjun Tang,*Ai Peng* Mol. Plant. 2023, 16, 1962-1975.

3. “Enantioselective transformations in the synthesis of therapeutic agents” He Yang,§ Hanxiao Yu,§ Izabela A. Stolarzewicz,* Wenjun Tang*Chem. Rev. 2023, 123, 9397-9446.

4. “Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Reductive Coupling of Ketimines Templated by Chiral Diborons” Mingkang Zhou,§ Yaodong Lin,§ Xiao-Xuan Chen,§ Guangqing Xu,* Lung Wa Chung,* Wenjun Tang*Angew. Chem., Int. Ed. 2023, 62, e202300334.

5. “Heck Reaction of N-Heteroaryl Halides for Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles” Bowen Li, Bangke Luo, He Yang,* Wenjun Tang* Angew. Chem., Int. Ed. 2022, 61, e202209087.

6. “Enantioselective Construction of ortho-Sulfur- or Nitrogen-Substituted Axially Chiral Biaryls and Asymmetric Synthesis of Isoplagiochin D” He Yang, Wenjun Tang* Nat. Commun. 2022, 13, 4577.

7. Enantioselective α-Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β'‐Diketones” Ting Wu, Qinghai Zhou, Wenjun Tang* Angew. Chem., Int. Ed. 2021, 60, 9978-9983.

8. Asymmetric Hydroesterification of Diarylmethyl Carbinols” Duanshuai Tian, Ronghua Xu, Jinbin Zhu, Jianxun Huang, Wei Dong, Jerome Claverie, Wenjun Tang* Angew. Chem., Int. Ed. 2021, 60, 6305-6309.

9. Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron” Mingkang Zhou, Kaidi Li, Dongping Chen, Ronghua Xu, Guangqing Xu, *Wenjun Tang* J. Am. Chem. Soc. 2020, 142, 10337-10342.

10. Enantioselective Cross-Coupling for Axially Chiral Tetra-ortho-Substituted Biaryls and Asymmetric Synthesis of Gossypol” He Yang, Jiawei Sun, Wei Gu, Wenjun Tang* J. Am. Chem. Soc. 2020, 142, 8036–8043.

11. Expedite Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization” Xingye Mu, Hanxiao Yu, Henian Peng, Wenrui Xiong, Ting Wu, Wenjun Tang* Angew. Chem., Int. Ed. 2020, 59, 8143-8147.

12. Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin” Jinbin Zhu, Linwei Huang, Wei Dong, Naikai Li, Xingxin Yu, Wei-Ping Deng, Wenjun Tang* Angew. Chem., Int. Ed. 2019, 58, 16119-16123.

13. Stereoelectronic Effects in Ligand Design: Enantioselective RhodiumCatalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib” Chengxi Li,§ Feng Wan,§ Yuan Chen, Henian Peng, Wenjun Tang,* Shu Yu,* J. Christopher McWilliams,* Jason Mustakis, Lacey Samp, Robert J. Maguire, Angew. Chem., Int. Ed. 2019, 58, 13573-13583.

14. Enantioselective Palladium-Catalyzed Cross-Coupling of α-Bromo Carboxamides and Aryl Boronic Acids” Bowen Li, Tiejun Li, Muinat A. Aliyu, Zhen Hua Li, Wenjun Tang*Angew. Chem., Int. Ed. 2019, 58, 11355-11359.

15. “Efficient Synthesis of (-)-Corynoline by Enantioselective Palladium Catalyzed α-Arylation with Sterically Hindered Substrates” Xiaofeng Rao,§ Naikai, Li,§ Heng Bai,§ Chaodi Dai, Zheng Wang, Wenjun Tang* Angew. Chem. Int. Ed. 2018, 57, 12328-12332.

16. “Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group” Duanshuai Tian,§ Chengxi Li,§ Guoxian Gu, Henian Peng, Xumu Zhang,* Wenjun Tang* Angew. Chem. Int. Ed. 2018, 57, 7176-7180.

17. “Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons” Dongping Chen, Guangqing Xu, Qinghai Zhou, Lung Wa Chung, Wenjun Tang* J. Am. Chem. Soc. 2017, 139,9767-9770.

18. Efficient Enantioselective Syntheses of (+)-Dalesconol A & BGuoqing Zhao, § Guangqing Xu, § Chao Qian, Wenjun Tang* J. Am. Chem. Soc. 2017, 1393360-3363.

19. Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles” Chengxi Li, Yuanyuan Zhang, Qi Sun, Tongnian Gu, Henian Peng, Wenjun Tang* J. Am. Chem. Soc. 2016, 138, 10774-10777.

20. “Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Ketones: Efficient Synthesis of Escitalopram” Linwei Huang, Jinbin Zhu, Guangjun Jiao, Zheng Wang, Xinxin Yu, Wei-Ping Deng,* Wenjun Tang* Angew. Chem., Int. Ed. 2016, 55, 4527.

21. “Synthesis of Chiral 1,4-Benzodioxanes and Chromans by Enantioselective Palladium-Catalyzed Alkene Aryloxyarylation” Naifu Hu, Ke Li, Zheng Wang, Wenjun Tang* Angew. Chem., Int. Ed. 2016, 55, 5044.

22. “Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides” Naifu Hu,§ Guoqing Zhao,§ Yuanyuan Zhang, Xiangqian Liu, Guangyu Li, Wenjun Tang* J. Am. Chem. Soc. 2015, 137, 6746-6749.

23. “Enantioselective Palladium-Catalyzed Dearomative Cyclization for Efficient Synthesis of Terpenes and Steroids” Kang Du, Pan Guo, Yuan Chen, Zheng Cao, Wenjun Tang* Angew. Chem., Int. Ed. 2015, 54, 3033.

24. “Efficient Syntheses of Sterically Hindered Acyclic Secondary Alkyl Arenes by Suzuki-Miyaura Cross-Couplings” Chengxi Li, Tianyu Chen, Guolan, Xiao, Bowen Li, Wenjun Tang* Angew. Chem., Int. Ed. 2015, 54, 3792.

25. “Highly Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Alkynone” Wenzhen Fu, Ming Nie, Aizhen Wang, Wenjun Tang* Angew. Chem., Int. Ed. 2015, 54, 2520.

承担科研项目情况

1 国家重点研发计划课题:钯催化偶联及催化剂创制,2022-2027年。

2 国家自然科学基金科学中心项目:神经系统疾病致病机理的研究和干预,2022-2026年。

3 国家杰出青年科学基金:催化不对称合成,2018-2022年。

4. 国家重点研发计划课题:高端金属与配体研制及关键技术研发,2021-2025年。

5. 广东省重点领域研发计划项目:三联芳膦钯碳氮偶联催化剂的研发及产业化,2020-2024年。

6. 上海市科委国家合作项目:有关磺酸化手性膦配体的材料科学,2018-2020年。

7. 国家自然科学基金面上项目:新型膦配体的发展2012-2015年。

8. 国家自然科学基金重点项目:新型、高效P-手性配体的基础和应用研究2015-2019年。

9. 国家自然科学基金面上项目:不对称环化反应方法学以及在天然产物和药物合成中的应用,2016-2019年。

10. 中国科学院战略性先导科技专项(B类):结构与功能导向的新物质创制,2016-2021年。

11.中国科学院前沿科学重点研究项目:配体促进的高效偶联反应研究,2016-2021年。