研究员
桂敬汉
职  称: 研究员
学  历: 博士研究生
电  话: 021-54925163
职  务:
传  真: 021-64166128
电子邮件: guijh@sioc.ac.cn
个人网页: http://guigroup.sioc.ac.cn
通信地址: 上海市徐汇区零陵路345号
个人简历

2003.9 - 2007.7     安徽师范大学化材学院,理学学士(导师:胡益民教授)

2007.9 - 2012.7     中国科学院上海有机化学研究所,理学博士(导师:田伟生研究员)

2012.7 - 2013.2     中国科学院上海有机化学研究所,研究助理

2013.2 - 2016.3     美国Scripps研究所化学系,博士后(导师: Phil S. Baran 教授)

2016.3 -       中国科学院上海有机化学研究所,研究员,课题组长,博士生导师


研究方向

甾体及萜类天然产物合成;新型碳-碳键成键和碎裂的合成方法学研究

社会任职
获奖及荣誉

2023   Asian Core Program Lectureship Award (Thailand)

2022   中国科学院大学领雁奖章

2022   中国科学院青年五四奖章(首届)

2022   Natural Product Reports Emerging Investigator Lectureship

2021   国家优秀青年科学基金

2021   科学探索奖

2021   中国科学院优秀导师奖

2021   上海科技青年35人引领计划(首届)

2020   中国化学会青年化学奖

2020   中国化学会菁青化学新锐奖

2020   EurJOC Lecture Award(首届)

2017  上海市青年科技启明星计划


代表论著

1.Wang, Y.; Gui, J.* Bioinspired Skeletal Reorganization Approach for the Synthesis of Steroid Natural Products. Acc. Chem. Res. 2024, 57, 568579.

2.Cen, K.; Bao, J.; Wang, X.; Tian, H.; Wang, Y.; Gui, J.* Bioinspired Divergent Synthesis of Aspersteroids A and B. J. Am. Chem. Soc. 2024, 146, 64816486.

3.Song, H.; Zhang, Z.; Cao, C.;* Tang, Z.;* Gui, J.;* Liu, W.* Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable the Concise Chemoenzymatic Synthesis of 9,10-Secosteroids. Angew. Chem. Int. Ed. 2024, 63, e202319624.

4.Wang, X.; Huang, G.; Wang, Y.; Gui, J.* Asymmetric Total Synthesis of the Rearranged Steroid Phomarol Enabled by a Biomimetic SN2′ Cyclization. J. Am. Chem. Soc. 2023, 145, 93549363.

5.Yang, P.; Li, Y.-Y.; Tian, H.; Qian, G.-L.; Wang, Y.; Hong, X.;* Gui, J.* Syntheses of Bufospirostenin A and Ophiopogonol A by a Conformation-Controlled Transannular Prins Cyclization. J. Am. Chem. Soc. 2022, 144, 1776917775.

6.Wang, Y.; Tian, H.; Gui, J.* Gram-Scale Synthesis of Bufospirostenin A by a Biomimetic Skeletal Rearrangement Approach. J. Am. Chem. Soc. 2021, 143, 1957619586.

7.Ju, W.; Wang, X.; Tian, H.; Gui, J.* Asymmetric Total Synthesis of Clionastatins A and B. J. Am. Chem. Soc. 2021, 143, 1301613021.

8.Li, X.; Zhang, Z.; Fan, H.; Miao, Y.; Tian, H.; Gu, Y.; Gui, J.* Concise Synthesis of 9,11-Secosteroids Pinnigorgiols B and E. J. Am. Chem. Soc. 2021, 143, 48864890.

9.Ning, Y.; Tian, H.; Gui, J.* Biogenesis-Guided Synthesis and Structural Revision of Sarocladione Enabled by Ruthenium-Catalyzed Endoperoxide Fragmentation. Angew. Chem. Int. Ed. 2021, 60, 1122211226 (VIP).

10.Wang, Y.; Chen, B.; He, X.; Gui, J.* Bioinspired Synthesis of Nortriterpenoid Propindilactone G. J. Am. Chem. Soc. 2020, 142, 50075012. 

11.Deng, J.; Ning, Y.; Tian, H.; Gui, J.* Divergent Synthesis of Antiviral Diterpenes Wickerols A and B. J. Am. Chem. Soc. 2020, 142, 46904695.

12.Wang, Y.; Ju, W.; Tian, H.; Sun, S.; Li, X.; Tian, W.; Gui, J.* Facile Access to Bridged Ring Systems via Point-to-Planar Chirality Transfer: Unified Synthesis of Ten Cyclocitrinols. J. Am. Chem. Soc. 2019, 141, 50215033.

13.Wang, Y.; Ju, W.; Tian, H.; Tian, W.; Gui, J.* Scalable Synthesis of Cyclocitrinol. J. Am. Chem. Soc. 2018, 140, 94139416.

14.Deng, J.; Wu, J.; Tian, H.; Bao, J.; Shi, Y.; Tian, W.;* Gui, J.* Alkynes From Furans: A General Fragmentation Method Applied to the Synthesis of the Proposed Structure of Aglatomin B. Angew. Chem. Int. Ed. 2018, 57, 36173621.

承担科研项目情况