张汉林实验室的主要研究方向为生物衰老。作为每个成年个体都正在亲身经历的生命历程，衰老现象始终激发着人类深刻的好奇心与同理心。随着20世纪末一系列衰老研究奠基性发现的问世，人类已经认识到衰老过程背后存在着复杂但有规律、可调控的分子与细胞学机制。研究这一现象不仅有助于揭示生命运行的基本规律，也在预防和治疗衰老相关疾病如神经退行、癌症、心脑血管疾病等方面具有重要的应用价值。基于前期在细胞自噬、线粒体胁迫、胞外基质重塑、免疫调控等衰老相关领域的积累，本课题组以未配对的括号或引号！细胞稳态调控的分子机制未配对的括号或引号！为核心研究方向，综合利用线虫、组织培养、小鼠等多种生物模型，结合细胞生物学、遗传学、分子生物学、免疫学、多组学分析等技术手段，从现象到机制、从分子到整体对衰老相关科学问题进行系统性探索。

具体研究方向包括：

（1）细胞内外稳态的调节与通讯机制；

（2）细胞稳态信号通路对机体免疫和衰老的调节；

（3）组织纤维化等衰老相关病变的发生与干预。

(*共同第一作者，#通讯作者)

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