1. 研究CED-3/caspase（或鉴定其它关键脂质代谢调控因⼦）如何调节脂质代谢以消除机体脂毒性进⽽预防衰老过程。

2. 揭示CED-3/caspase（或其它关键调控因⼦）如何抵抗UV辐射导致的衰⽼及死亡 。

3. 揭示CED-3/caspase调控运动神经元细胞损伤后的轴突再⽣修复机制。

2023年美国西南医学中心 Alfred & Mabel Gilman Memorial Excellent Post-Doc. Scientific Research Award

2014年国家公派留学奖学金

#co-first authorship *corresponding author

1. Hai Wei, Yi M. Weaver, Benjamin P. Weaver2024 Xeroderma pigmentosum protein XPD controls caspase- mediated stress responses. Nature Communications PMID: 39472562, DOI:https://doi.org/10.1038/ s41467-024-53755-8

2. Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinisand Benjamin P. Weaver2024 Proteolytic Activation of Fatty Acid Synthase Signals Pan-Stress Resolution. Nature Metabolism. PMID: 38167727, DOI: 10.1038/s42255-023-00939-z (Cover Article, Highlighted and collected by Nature Metabolism)

3. Aditya Sethi#, Hai Wei#, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin and Barbara Conradt 2022 A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans. PLOS Biology PMID: 36201522, DOI: 10.1371/journal.pbio.3001786 (#equal contribution)

4. Hai Wei, Lambie EJ, Oso´rio DS, Carvalho AX, Conradt B. 2020 PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLOS Genetics PMID: 32946434, DOI: 10.1371/journal.pgen.1008912

5. W. Deng, Jack A. Bates, Hai Wei, Michael D. Bartoschek, Barbara Conradt & Heinrich Leonhardt, 2020 Tunable light and drug induced depletion of target proteins. Nature Communications PMID: 31949141, DOI:10.1038/s41467-019 -14160-8

6. Mishra N., Hai Wei, and B. Conradt, 2018 Caenorhabditis elegans ced-3 Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die. GENETICS PMID: 30194072, DOI:10.1534/genetics. 118.301500

7. Hai Wei#, Bo Yan#, J. Gagneur, and B. Conradt, 2017 Caenorhabditis elegans ces-1 Snail represses pig-1 MELK expression to control asymmetric cell division. GENETICS PMID: 28652378, DOI:10.1534/genetics.117.202754 (#equal contribution)

8. Qingliang Li#, Hai Wei#, Lijing Liu, Xiaoyuan Yang, Xiansheng Zhang, Qi Xie, 2017 Unfolded protein response activation compensates endoplasmic reticulum-associated degradation deficiency in Arabidopsis. Journal of Integrative Plant Biology PMID: 28418178, DOI: 10.1111/jipb.12544 (#equal contribution)