研究员
王震
职  称: 研究员
学  历: 博士研究生
电  话: 021-54925133
职  务:
传  真:
电子邮件: wangz@sioc.ac.cn
个人网页:
通信地址: 上海市零陵路345号
个人简历
20079-20117 合肥工业大学 本科

20119-20167 中科院广州生物医药与健康研究院 博士(导师:丁克)

20168-20215 美国H. Lee Moffitt Cancer Center & Research Institute 博士后(导师:季海涛)

20216-至今     中科院上海有机化学研究所 研究员

研究方向
激酶抑制剂

激酶非催化功能发现和小分子调控

社会任职
 
获奖及荣誉
代表论著

1. Zhen Wang#; Min Zhang#; Victor Quereda#; Sylvia M. Frydman; Qianqian Ming; Vincent C. Luca; Derek R. Duckett*; Haitao Ji*. Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction. J. Med. Chem. 2016, 59, 1078–1101.

2. Zhen Wang#; Min Zhang#; Wen Luo; Yongqiang Zhang; Haitao Ji*. Discovery of 2-(3-(3-Carbamoylpi peridin-1–yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein?Protein Interaction. J. Med. Chem. 2021, 64, 5886–5904.

3. Zhen Wang#; Zilu Li#; Haitao Ji*. Direct Targeting of β‐Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives. Med. Res. Rev. 2021, 41, 2109-2129.

4. Qiuju Xun#; Zhen Wang#; Xianglong Hu; Ke Ding*; Xiaoyun Lu*. Small Molecule CSF1R Inhibitors as Anticancer Agents. Curr. Med. Chem. 2020, 27, 3944-3966.

5. Zhen Wang#; Min Zhang#; Jin Wang; Haitao Ji*. Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein?Protein Interaction. J. Med. Chem. 2019, 62, 3617-3635.

6. Zhen Wang#; Yali Zhang#; Daniel M. Pinkas#; Alice E. Fox; Jinfeng Luo; Huocong Huang; Shengyang Cui; Qiuping Xiang; Tingting Xu; Qiuju Xun; Dongsheng Zhu; Zhengchao Tu; Xiaomei Ren; Rolf A. Brekken; Alex N. Bullock; Guang Liang*; Ke Ding*; Xiaoyun Lu*. Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as Dual Inhibitors of Discoidin Domain Receptor 1 and 2 (DDR1/2). J. Med. Chem. 2018, 61, 7977-7990.

7. Min Zhang#; Zhen Wang#; Yongqiang Zhang; Wenxing Guo; Haitao Ji*. Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B Cell Lymphoma 9 Protein–Protein Interaction. J. Med. Chem. 2018, 61, 2989-3007.

8. Zhen Wang#; Yali Zhang#; Sergio G. Bartual; Jinfeng Luo; Tingting Xu; Wenting Du; Qiuju Xun; Zhengchao Tu; Rolf A. Brekken; Xiaomei Ren; Alex N. Bullock*; Guang Liang*; Xiaoyun Lu*; Ke Ding*. Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Med. Chem. Lett., 2017, 8, 327-332.

9. Zhen Wang#; Huan Bian#; Sergio G. Bartual#; Wenting Du; Jinfeng Luo; Hu Zhao; Shasha Zhang; Cheng Mo; Yang Zhou; Yong Xu; Zhengchao Tu; Xiaomei Ren; Xiaoyun Lu; Rolf A. Brekken; Libo Yao; Alex N. Bullock*; Jin Su*; Ke Ding*. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem., 2016, 59, 5911-5916. (Cover paper)

承担科研项目情况