2013年9月 ~ 至今： 中国科学院上海有机化学研究所 研究员、课题组长
2008年6月 ~ 2013年8月： 美国霍华德休斯医学研究院 博士后/助理研究员
2008年1月 ~ 2008年5月： 美国宾夕法尼亚大学 博士后
2002年9月 ~ 2007年12月：美国宾夕法尼亚大学 神经科学博士学位
1997年9月 ~ 2002年7月: 北京大学医学部 医学学士学位
神经轴突退化变性坏死是急性神经损伤如脊髓损伤和脑创伤以及很多与衰老相关的慢性神经退行性疾病如老年痴呆症(AD)、帕金森氏症(PD)、亨廷顿氏症(HD)、多发性硬化症(MS)、肌萎缩性脊髓侧索硬化症(ALS)等疾病中的常见病变。此外，糖尿病、青光眼和化疗引起的神经毒性也会导致继发性的神经轴突的退化变性坏死。由于人类的中枢神经在受损或变性坏死后再生能力极其有限，如何保护受损或患病的神经，预防、延缓、阻止乃至逆转神经轴突退化变性坏死是生物医学领域的一个重大前沿课题。
方燕姗课题组致力于急性神经损伤和慢性退行性疾病中神经退化的细胞和分子机理的研究，运用全新的神经损伤活体动物模型结合分子遗传学、细胞生物学、生物化学、药物化学、超高分辨率荧光成像、新一代测序技术、现代蛋白质组学和代谢组学等技术研究调控神经退化和促进神经再生修复的分子机制，并以此作为基础开发用于疾病诊断治疗的生物标志物和新型药物。
2023年 获得国家杰出青年科学基金
2023年 入选首批上海浦东“明珠计划”领军人才
2014年 入选国家高技术研究发展计划（863计划）青年科学家
2014年 入选国家高层次人才计划青年项目
1. Shu S, Jiang M, Deng X, Yue W, Cao X, Zhang K, Wang Z, He H, Cui J, Wang Q, Qu K and FANG Y#. (2023) “Heterochromatic silencing of immune-related genes in glia is required for BBB integrity and normal lifespan in Drosophila.” Aging Cell, 22:e13947.
2. Yue W, Zhang K, Jiang M, Long W, Cui J, Li Y, Zhang Y, Li A# and FANG Y#. (2023) “Deubiquitination of SARM1 by USP13 regulates SARM1 activation and axon degeneration”. Life Medicine, 2(5):1-12.
3. Yue W, Tang CW and FANG Y#. (2023) “PIKFYVEinhibition, a neuronal “emetic” for treating ALS?” Neuroscience Bulletin, 39(11):1738-1740.
4. Yue W, Deng X, Wang Z, Jiang M, Hu R, Duan Y, Wang Q, Cui J and FANG Y#. (2023) “Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS.” Immunity & Ageing, 20(1):27.
5. Ni J, Ren Y, Su T, Zhou J, Fu C, Yi Lu, Li D, Zhao J, Li Y, Zhang Y, FANG Y, Liu N, Geng Y# and Chen Y#. (2023) “Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies.” Molecular Psychiatry 28(2): 931-945.
6. Hu R, Qian B, Li A# and FANG Y#. (2022) “Role of Proteostasis Regulation in the Turnover of Stress Granules.” Int J Mol Sci, 23(23):14565.
7. Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A# and FANG Y#. (2022) “CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.” Journal of Cell Biology, 221(1): e202103033.
8. Li Y, Gu J, Wang C, Hu J, Zhang S, Liu C, Zhang S, FANG Y and Li D#. (2022) “Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation.” iScience. 25(6):104356.
9. Huang C, Lu J, Ma X, Qiang J, Wang C, Liu C, FANG Y, Zhang Y, Jiang L, Li D# and Zhang S#. (2022) “The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins.” Journal of Biological Chemistry, 298(5):101912.
10. Zhang K, Jiang M and FANG Y#. (2021) “The drama of Wallerian degeneration: the cast, crew and script.” Annual Review of Genetics, 55:93-113.
11. Zhang K, Wang Q, Liang Y, Yan Y, Wang H, Cao X, Shan B, Zhang Y#, Li A# and FANG Y#. (2021) “Quantitative proteomic analysis of mouse sciatic nerve reveals post-injury upregulation of ADPGK promoting macrophage phagocytosis.” Frontier in Molecular Neuroscience, 14:777621.
12. Gu J, Wang C, Hu R, Li Y, Zhang S, Sun Y, Wang Q, Li D, FANG Y# and Liu C#. (2021) “Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation.” Cell Research, 31(9):1024-1027.
13. Wang H, Zhang Y, Zeng K, Qiang J, Cao Y, Li Y, FANG Y, Zhang Y# and Chen Y#. (2021) “Selective mitochondrial protein labeling enabled by biocompatible photocatalytic reactions inside live cells.” JACS Au, 1(7):1066-1074.
14. Sun Y, Zhao K, Xia W, Feng G, Gu J, Ma Y, Gui X, Zhang X, FANG Y, Sun B, Wang R, Liu C# and Li D#. (2020) “The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure.” Nature Communications, 11(1):6349.
14. Gu J, Liu Z, Zhang S, Li Y, Xia W, Wang C, Xiang H, Liu Z, Tan L, FANG Y, Liu C# and Li D#. (2020) “Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles.” Proc Natl Acad Sci U S A, 117(49):31123-31133.
15. Wang C, Duan Y, Duan G, Wang Q, Zhang K, Deng X, Qian B, Gu J, Ma Z, Zhang S, Guo L, Liu C# and FANG Y#. (2020) “Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies via paraspeckle lncRNA NEAT1-mediated liquid-liquid phase separation.” Molecular Cell, 79(3):443-458.e7. (Highlighted with commentary by Malik and Barmada in Molecular Cell)
16. Ma X, Zhu Y, Lu J, Xie J, Li C, Shin WS, Qiang J, Liu J, Dou S, Xiao Y, Wang C, Jia C, Long H, Yang J, FANG Y, Jiang L, Zhang Y, Zhang S, Zhai RG#, Liu C# and Li D#. (2020) “Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau.” Elife, 9. pii:e51859.
17. Liu C# and FANG Y#. (2019) “New insights of poly(ADP-ribosylation) in neurodegenerative diseases: a focus on protein phase separation and pathologic aggregation.” Biochemical Pharmacology, 167:58-63.
18. Duan Y, Du A, Gu J, Duan G, Wang C, Gui X, Ma Z, Qian B, Deng X, Zhang K, Sun L, Tian K, Zhang Y, Jiang H, Liu C# and FANG Y#. (2019) “PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins.” Cell Research, 29(3):233-247.
19. Wang H, Wang X, Zhang K, Wang Q, Cao X, Wang Z, Zhang S, Li A# Liu K# and FANG Y#. (2019) “Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration.” Science Advances, 5(2):eaav4971.
20. Yang L, Cao Y, Zhao J, FANG Y, Liu N# and Zhang Y#. (2019) “Multidimensional proteomics identifies declines in protein homeostasis and mitochondria as early signals for normal aging and age-associated disease in Drosophila.” Mol Cell Proteomics, 8(10):2078-2088.
21. Sun X, Duan Y, Qin C, Li JC, Duan G, Deng X, Ni J, Cao X, Xiang K, Tian K, Chen CH, Li A# and FANG Y#. (2018) “Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy.” Cell Death & Disease, 9(10):953.
22. Cao X, Wang H, Wang Z, Wang Q, Zhang S, Deng Y and FANG Y#. (2017) “In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging.” Aging Cell, 16(5):1180-1190.
23. Cao X and FANG Y#. (2015) “Transducing oxidative stress to death signals in neurons.” Journal of Cell Biology, 211(4):741-743.
24. FANG Y# and Boinini NM#. (2015) “Hope on the fruit fly - The Drosophila wing paradigm of axon injury.” Neural Regeneration Research, 10(2):173-175.
25. Huang Q, Yang L, Luo J, Guo L, Wang Z, Yang X, Jin W, FANG Y, Ye J, Shan B# and Zhang Y#. (2015) “SWATH enables precise label-free quantification on proteome scale.” Proteomics, 15(7):1215-23.
26. FANG Y, Soares L and Bonini NM#. (2013) “Design and implementation of in vivo imaging of neural injury responses in the adult Drosophila wing.” Nature Protocols, 8(4): 810-819.
27. Garbe DS, FANG Y, Zheng X, Sowcik M, Anjum R, Gygi SP and Sehgal A#. (2013) “Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.” PLoS Genetics, 9(9): e1003749.
28. FANG Y and Boinini NM#. (2012) “Axon degeneration and regeneration: insights from Drosophila models of nerve injury.” Annual Review of Cell and Developmental Biology, 28:575-597.
29. FANG Y, Soares L, Teng X, Geary M and Bonini NM#. (2012) “A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity.” Current Biology, 22(7):590-595. (Highlighted with commentary by Wang and Barres in Current Biology; Recommended by Faculty of 1000)
30. FANG Y and Sehgal A#. (2010) “Protein phosphatases and circadian clocks.” in Handbook of Cell Signaling, 2nd Edition, eds. Bradshaw, R. A. & Dennis, E. A. Oxford:Academic Press, pp. 877-882.
31. Wu Y, Bolduc FV, Bell K, Tully T, FANG Y, Sehgal A and Fischer JA#. (2008) “A Drosophila model for Angelman syndrome.” Proc Natl Acad Sci U S A, 105(34):12399-12404.
32. FANG Y, Sathyanarayanan S and Sehgal A#. (2007) “Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1).” Genes & Development, 21(12):1506-1518.
33. Sehgal A, Joiner W, Crocker A, Koh K, Sathyanarayanan S, FANG Y, Wu M, Williams J and Zheng X#. (2007) “Molecular analysis of sleep:wake cycles in Drosophila.” Cold Spring Harb Symp Quant Biol, 72:557-564.
34. Stein JM, Bergman W, FANG Y, Davison L, Brensinger C, Robinson MB, Hecht NB and Abel T#. (2006) “Behavioral and neurochemical alterations in mice lacking the RNA-binding protein Translin.” Journal of Neuroscience, 26(8):2184-2196.
