2024年

1. Kaien Liu #, Youqi Tao #, Qinyue Zhao, Wencheng Xia, Xiang Li, Shenqing Zhang, Yuxuan Yao, Huaijiang Xiang, Chao Han, Li Tan, Bo Sun, Dan Li, Ang Li, Cong Liu*. Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils. Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2321633121. doi: 10.1073/pnas.2321633121. Epub 2024 Aug 22.

2. Jiaojiao Hu*, Hui Dong, Yichen Li, Jinge Gu, Liang Yang, Chenfang Si, Yaoyang Zhang, Tingting Li , Dan Li*, Cong Liu*. Hsp90α forms condensate engaging client proteins with RG motif repeats. Chem Sci. 2024 Jun 10;15(27):10508-10518. doi: 10.1039/d4sc00267a. eCollection 2024 Jul 10.

3. Chunyu Zhao, Jia Tu, Chuchu Wang, Wenbin Liu, Jinge Gu, Yandong Yin, Shengnan Zhang, Dan Li, Jiajie Diao*, Zheng-Jiang Zhu*, Cong Liu*. Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation. Natl Sci Rev. 2024 May 25;11(6):nwae182. doi: 10.1093/nsr/nwae182. eCollection 2024 Jun.

4. Yilin Zhao#, Lijuan Guo#, Jiaojiao Hu#, Zhiyun Ren, Yanan Li, Meng Hu, Xia Zhang, Lulu Bi, Dan Li, Hanhui Ma, Cong Liu*, Bo Sun*. Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex. Nucleic Acids Res. 2024 Aug 12;52(14):8385-8398. doi: 10.1093/nar/gkae533.

5. Jinjian Hu#, Wencheng Xia#, Shuyi Zeng#, Yeh-Jun Lim#, Youqi Tao, Yunpeng Sun, Lang Zhao, Haosen Wang, Weidong Le, Dan Li, Shengnan Zhang, Cong Liu*, Yan-Mei Li*. Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures. Nat Commun. 2024 Mar 27;15(1):2677. doi: 10.1038/s41467-024-46898-1.

6. Shuang Hou #, Jiaojiao Hu #, Zhaowei Yu, Dan Li, Cong Liu*, Yong Zhang*. Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions. Nat Commun. 2024 Mar 8;15(1):2147. doi: 10.1038/s41467-024-46445-y.

7. Wanbing Zhao, Kaien Liu, Yun Fan, Qinyue Zhao, Youqi Tao, Mengwei Zhang, Linhua Gan, Wenbo Yu, Bo Sun, Dan Li, Cong Liu*, Jian Wang*. Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies. Cell Discov. 2024 Mar 7;10(1):27. doi: 10.1038/s41421-023-00637-w.

8. Yunqi Jiang#, Jinge Gu#, Xiaodou Niu#, Jiaojiao Hu, Yongzhen Zhang, Dan Li, Yida Tang, Cong Liu*, Zijian Li*. Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure. Circulation, 2024 Feb 8. doi: 10.1161/CIRCULATIONAHA.123.067519. 

2023年

9. Ying Lai#, Chunyu Zhao#, Zhiqi Tian#, Chuchu Wang#, Jiaqi Fan#, Xiao Hu, Jia Tu, Tihui Li, Jeremy Leitz, Richard A Pfuetzner, Zhengtao Liu, Shengnan Zhang, Zhaoming Su, Jacqueline Burré, Dan Li, Thomas C Südhof, Zheng-Jiang Zhu, Cong Liu*, Axel T Brunger*, Jiajie Diao*. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2310174120. doi: 10.1073/pnas.2310174120. Epub 2023 Oct 26.

10. Yulong Bai#, Shengnan Zhang#, Hui Dong#, Yu Liu, Cong Liu*, Xin Zhang*. Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments. Chem Rev. 2023 Nov 8;123(21):12254-12311. doi: 10.1021/acs.chemrev.3c00494. Epub 2023 Oct 24. (Invited review) (Cover)

11. Fenghua Wang#, Wencheng Xia#, Mingming Zhang, Rongrong Wu, Xiaolu Song, Yun Hao, Yonghai Feng, Liwei Zhang, Dan Li, Wenyan Kang, Cong Liu*, Lei Liu*. Engineering of antimicrobial peptide fibrils with feedback degradation of bacterial-secreted enzymes. Chem Sci. 2023 Sep 7;14(39):10914-10924. doi: 10.1039/d3sc01089a. eCollection 2023 Oct 11.

12. Cong Liu*, Xin Zhang*. Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective. Curr Opin Chem Biol.  2023 Dec;77:102386. doi: 10.1016/j.cbpa.2023.102386. Epub 2023 Sep 4. (Invited review)

13. Dan Li*, Cong Liu*. Molecular rules governing the structural polymorphism of amyloid fibrils in neurodegenerative diseases. Structure. 2023 Nov 2;31(11):1335-1347. doi: 10.1016/j.str.2023.08.006. Epub 2023 Aug 31. (Invited review)

14. Danni Li#, Yeyang Ma#, Wencheng Xia, Youqi Tao, Yiling Zhang, Hong Zhang, Dan Li, Bin Dai*, Cong Liu*. Creating an amyloid 'kaleidoscope' using short iodinated peptides. Angew Chem Int Ed Engl. 2023 Oct 16;62(42):e202310737. doi: 10.1002/anie.202310737. Epub 2023 Sep 12.

15. Cong Liu* (guest editor) The riverdance of proteins within the cell: a special issue on protein phase separation in biology and diseases. Acta Biochim Biophys Sin (Shanghai), 2023, 55(7):1021-1022.

16. Youqi Tao#, Wencheng Xia#, Qinyue Zhao#, Huaijiang Xiang, Chao Han, Shenqing Zhang, Wei Gu, Wenjun Tang, Ying Li, Li Tan, Dan Li*, Cong Liu*. Structural mechanism for specific binding of chemical compounds to amyloid fibrils. Nat Chem Biol. 2023 Oct;19(10):1235-1245. doi: 10.1038/s41589-023-01370-x. Epub 2023 Jul 3.

17. Xinyu Wang#, Shengnan Zhang#, Jicong Zhang, Yaomin Wang, Xiaoyu Jiang, Youqi Tao, Dan Li, Chao Zhong*, Cong Liu*. Rational design of functional amyloid fibrillar assemblies. Chem Soc Rev. 2023 Jul 17;52(14):4603-4631. doi: 10.1039/d2cs00756h. (Invited review) (Cover)

18. Yan Wang#, Xiaobin Ling#, Chong Zhang, Jian Zou, Bingnan Luo, Yongbo Luo, Xinyu Jia, Guowen Jia, Minghua Zhang, Junchao Hu, Ting Liu, Yuanfeiyi Wang, Kefeng Lu, Dan Li, Jinbiao Ma*, Cong Liu*, Zhaoming Su*. Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly. Mol Biomed. 2023 May 22;4(1):16. doi: 10.1186/s43556-023-00129-z.

19. Xiang Li#, Pinou Lv#, Yifei Du#, Xing Chen*, Cong Liu*. Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions. Curr Opin Chem Biol. 2023 Aug;75:102314. doi: 10.1016/j.cbpa.2023.102314. Epub 2023 May 6. (Invited review)

20. Qianhui Xu, Yeyang Ma, Yunpeng Sun, Dan Li, Xin Zhang*, Cong Liu*. Protein amyloid aggregate: Structure and function. Aggregate. 2023 Aug;4(4):e333. Epub 2023 Mar 10. (Invited review)

21. Shengnan Zhang#, Juan Li#, Qianhui Xu#, Wencheng Xia, Youqi Tao, Chaowei Shi, Dan Li, ShengQi Xiang*, Cong Liu*. Conformational Dynamics of an alpha-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy. J Am Chem Soc. 2023 Mar 1;145(8):4473-4484. doi: 10.1021/jacs.2c10854. Epub 2023 Feb 16.

22. Shenqing Zhang, Hui Dong, Jiang Bian, Dan Li, Cong Liu*. Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases. Fundam Res. 2023 Jul;3(4):505-519. Epub 2022 Nov 1. (Invited review)

23. Yichen Li, Jinge Gu, Cong Liu*, Dan Li*. A High-Throughput Method to Profile Protein Liquid-Liquid Phase Separation. Methods Mol Biol. 2023;2563:261-268. doi: 10.1007/978-1-0716-2663-4_13.

2022年

24. Qi Wang#, Zhouxian Li#, Shenqing Zhang#, Yichen Li, Yan Wang, Zheng Fang, Yanni Ma, Zhen Liu, Weibing Zhang, Dan Li, Cong Liu*, Mingliang Ye*. Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect-based chemical enrichment method. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2205255119. doi: 10.1073/pnas.2205255119. 

25. Houfang Long#, Shengnan Zhang#, Shuyi Zeng, Yilun Tong, Jun Liu, Cong Liu*, Dan Li*. Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia. Cell Rep. 2022 Sep 20;40(12):111401. doi: 10.1016/j.celrep.2022.111401.

26. Teng Wang#, Jiaojiao Hu#, Yanan Li, Lulu Bi, Lijuan Guo, Xinshuo Jia, Xia Zhang, Dan Li, Xi-Miao Hou, Mauro Modesti, Xu-Guang Xi6, Cong Liu*, Bo Sun*. Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates. Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202209463. doi: 10.1002/anie.202209463.

27. Youqi Tao#, Yunpeng Sun#, Shiran Lv, Wencheng Xia, Kun Zhao, Qianhui Xu, Qinyue Zhao, Lin He, Weidong Le, Yong Wang, Cong Liu*, Dan Li*. Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology. Nat Commun. 2022 Jul 22;13(1):4226. doi: 10.1038/s41467-022-31790-7.

28. Chao Gao, Jinge Gu, Hong Zhang, Kai Jiang, Linlin Tang, Ren Liu, Li Zhang, Pengfei Zhang, Cong Liu*, Bin Dai*, Jie Song*. Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus. Cell Rep. 2022 Jul 19;40(3):111086. doi: 10.1016/j.celrep.2022.111086.

29. Li-Qiang Wang#, Yeyang Ma#, Han-Ye Yuan#, Kun Zhao, Mu-Ya Zhang, Qiang Wang, Xi Huang, Wen-Chang Xu, Bin Dai, Jie Chen, Dan Li, Delin Zhang, Zhengzhi Wang, Liangyu Zou, Ping Yin, Cong Liu*, Yi Liang*. Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nat Commun. 2022 Jun 17;13(1):3491. doi: 10.1038/s41467-022-31240-4.

30. Dan Li*, Cong Liu*. Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nat Rev Neurosci. 2022 Sep;23(9):523-534. doi: 10.1038/s41583-022-00603-7. (Invited review)

31. Yichen Li#, Ginge Gu#, Cong Liu*, Dan Li*. A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation. Cell Rep Phys Sci. 2022 May 5;25(6):104356. doi: 10.1016/j.isci.2022.104356. 

32. Yun Fan#, Qinyue Zhao#, Wencheng Xia#, Youqi Tao, Wenbo Yu, Mingjia Chen, Yiqi Liu, Jue Zhao, Yan Shen, Yunpeng Sun, Chenfang Si, Shenqing Zhang, Yaoyang Zhang, Wensheng Li, Cong Liu*, Jian Wang*, Dan Li*. Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Res. 2022 Jun;32(6):585-588. doi: 10.1038/s41422-022-00665-3.

33. Shaobo Zhu#, Jinge Gu#, Juanjuan Yao, Yichen Li, Zheting Zhang, Wencheng Xia, Zhen Wang, Xinrui Gui, Leiting Li, Dan Li, Heng Zhang*, Cong Liu*. Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis. Dev Cell. 2022 Mar 14;57(5):583-597.e6. doi: 10.1016/j.devcel.2022.02.005.

34. Houfang Long, Shuyi Zeng, Yunpeng Sun, Cong Liu*. Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophys Rep. 2022 Feb 28;8(1):42-54. doi: 10.52601/bpr.2022.210032.

35. Dan Li*, Cong Liu*. Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks. Trends Cell Biol. 2022 Jan;32(1):1-3. doi: 10.1016/j.tcb.2021.08.004.  (Invited review)

2021年

36. Yunpeng Sun#, Shenqing Zhang#, Jiaojiao Hu#, Youqi Tao, Wencheng Xia, Jinge Gu, Yichen Li, Qin Cao, Dan Li, Cong Liu*. Molecular structure of an amyloid fibril formed by FUS low-complexity domain. iScience. 2021 Dec 27;25(1):103701. doi: 10.1016/j.isci.2021.103701. 

37. Dangliang Liu#, Qijia Wei#, Wencheng Xia#, Changdong He, Qikai Zhang, Lu Huang, Xiaoya Wang, Yunpeng Sun, Yeyang Ma, Xiaohui Zhang, Yuan Wang, Xiaomeng Shi, Cong Liu*, Suwei Dong*. O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation. J Am Chem Soc. 2021 Dec 8;143(48):20216-20223. doi: 10.1021/jacs.1c08607. 

38. Yunpeng Sun#, Houfang Long#, Wencheng Xia, Kun Wang, Xia Zhang, Bo Sun, Qin Cao, Yaoyang Zhang, Bin Dai, Dan Li*, Cong Liu*. The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein. Nat Commun. 2021 Oct 29;12(1):6252. doi: 10.1038/s41467-021-26433-2.

39. Li-Qiang Wang#, Kun Zhao#, Han-Ye Yuan#, Xiang-Ning Li, Hai-Bin Dang, Yeyang Ma,Qiang Wang, Chen Wang, Yunpeng Sun, Jie Chen, Dan Li, Delin Zhang, Ping Yin, Cong Liu*, Yi Liang*. Genetic prion disease–related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Sci Adv. 2021 Sep 10;7(37):eabg9676. doi: 10.1126/sciadv.abg9676.

40. Jinge Gu#, Chen Wang#, Rirong Hu#, Yichen Li, Shengnan Zhang, Yunpeng Sun, Qiangqiang Wang, Dan Li, Yanshan Fang*, Cong Liu*. Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. Cell Res. 2021 Sep;31(9):1024-1027. doi: 10.1038/s41422-021-00526-5. 

41. Shengnan Zhang#, Yu-Qing Liu#, Chunyu Jia#, Yeh-Jun Lim#, Guoqin Feng#, Enquan Xu, Houfang Long, Yasuyoshi Kimura, Youqi Tao, Chunyu Zhao, Chuchu Wang, Zhenying Liu, Jin-Jian Hu,Meng-Rong Ma, Zhijun Liu, Lin Jiangj, Dan Li, Renxiao Wang, Valina L. Dawson,Ted M. Dawson, Yan-Mei Li*, Xiaobo Mao*, Cong Liu*. Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson’s disease. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2011196118. doi: 10.1073/pnas.2011196118.

42. Houfang Long#, Weitong Zheng#, Yang Liu, Yunpeng Sun, Kun Zhao, Zhenying Liu, Wencheng Xia, Shiran Lv, Zhengtao Liu, Dan Li, Kai-Wen He*, Cong Liu*. Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2012435118. doi: 10.1073/pnas.2012435118.

43. Xialian Wu#, Yeyang Ma#, Kun Zhao#, Jing Zhang, Yunpeng Sun, Yichen Li, Xingqi Dong, Hong Hu, Jing Liu, Jian Wang, Xia Zhang, Bing Li, Huayi Wang, Dan Li, Bo Sun, Junxia Lu*, Cong Liu*. The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2022933118. doi: 10.1073/pnas.2022933118.

44. Youqi Tao#, Jingfei Xie#, Qinglu Zhong#, Yongyao Wang#, Shengnan Zhang, Feng Luo, Fengcai Wen, Jingjing Xie, Jiawei Zhao, Xiaoou Sun, Houfang Long, Junfeng Ma, Qian Zhang, Jiangang Long, Xianyang Fang, Ying Lu, Dan Li, Ming Li, Jidong Zhu, Bo Sun, Guohui Li*, Jiajie Diao*, Cong Liu*.A novel partially-open state of SHP2 points to a "multiple gear" regulation mechanism. J Biol Chem. 2021 Jan-Jun;296:100538. doi: 10.1016/j.jbc.2021.100538. 

45. Dan Li*, Cong Liu*. Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease. Nat Chem Biol.  2021 Mar;17(3):237-245. doi: 10.1038/s41589-020-00708-z.  (Invited review)

2020年

46. Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Guoqin Feng, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Renxiao Wang, Cong Liu*, Dan Li*. The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure. Nat Commun. 2020 Dec 11;11(1):6349. doi: 10.1038/s41467-020-20227-8.

47. Jinge Gu#, Zhenying Liu#, Shengnan Zhang, Yichen Li, Wencheng Xia, Chen Wang, Huaijiang Xiang, Zhijun Liu, Li Tan, Yanshan Fang, Cong Liu*, Dan Li*. Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31123-31133. doi: 10.1073/pnas.2002437117.

48. Guangya Zhu#, Jingjing Xie#, Wenna Kong#, Jingfei Xie#, Yichen Li, Lin Du, Qiangang Zheng, Lin Sun, Mingfeng Guan, Huan Li, Tianxin Zhu, Hao He, Zhenying Liu, Xi Xia, Chen Kan, Youqi Tao, Hong C. Shen, Dan Li, Siying Wang, Yongguo Yu, Zhi-Hong Yu, Zhong-Yin Zhang, Cong Liu*, Jidong Zhu*. Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation. Cell. 2020 Oct 15;183(2):490-502.e18. doi: 10.1016/j.cell.2020.09.002.

49. Kun Zhao#, Yeh-Jun Lim#, Zhenying Liu#, Houfang Long, Yunpeng Sun, Jin-Jian Hu, Chunyu Zhao, Youqi Tao, Xing Zhang, Dan Li, Yan-Mei Li*, Cong Liu*. Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20305-20315. doi: 10.1073/pnas.1922741117. Epub 2020 Jul 31.

50. Chen Wang#, Yongjia Duan#, Gang Duan#, Qiangqiang Wang, Kai Zhang, Xue Deng, Beituo Qian, Jinge Gu, Zhiwei Ma, Shuang Zhang, Lin Guo, Cong Liu*, Yanshan Fang*. Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation. Mol Cell. 2020 Aug 6;79(3):443-458.e7. doi: 10.1016/j.molcel.2020.06.019.

51. Hong Zhang*, Xiong Ji*, Pilong Li*, Cong Liu*, Jizhong Lou*, Zheng Wang*, Wenyu Wen*, Yue Xiao*, Mingjie Zhang*, Xueliang Zhu*. Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases. Sci China Life Sci. 2020 Jul;63(7):953-985. doi: 10.1007/s11427-020-1702-x.  (Invited review)

52. Li-Qiang Wang#, Kun Zhao#, Han-Ye Yuan, Qiang Wang, Zeyuan Guan, Jing Tao, Xiang-Ning Li, Yunpeng Sun, Chuan-Wei Yi, Jie Chen, Dan Li, Delin Zhang, Ping Yin, Cong Liu*, Yi Liang*. Cryo-EM structure of an amyloid fibril formed by full-length human prion protein. Nat Struct Mol Biol. 2020 Jun;27(6):598-602. doi: 10.1038/s41594-020-0441-5. 

53. Kun Zhao#, Yaowang Li#, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-Dong Su, Dan Li*, Xueming Li*, Cong Liu*. Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure. Nat Commun. 2020 May 26;11(1):2643. doi: 10.1038/s41467-020-16386-3.

54. Jinxia Lu#, Shengnan Zhang#, Xiaojuan Ma, Chunyu Jia, Zhenying Liu, Chengan Huang, Cong Liu*, Dan Li*. Structural basis of the interplay between alpha-synuclein and Tau in regulating pathological amyloid aggregation. J Biol Chem. 2020 May 22;295(21):7470-7480. doi: 10.1074/jbc.RA119.012284. 

55. Xiaojuan Ma#, Yi Zhu#, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu Wang, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai*, Cong Liu*, Dan Li*. Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau. Elife. 2020 Apr 6;9:e51859. doi: 10.7554/eLife.51859.

56. Zhenying Liu#, Shengnan Zhang#, Jinge Gu#, Yilun Tong, Yichen Li, Xinrui Gui, Houfang Long, Chuchu Wang, Chunyu Zhao, Jinxia Lu, Lin He, Ying Li, Zhijun Liu, Dan Li*, Cong Liu*. Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. Nat Struct Mol Biol. 2020 Apr;27(4):363-372. doi: 10.1038/s41594-020-0399-3. 

57. Chuchu Wang, Jia Tu, Shengnan Zhang, Bin Cai, Zhenying Liu, Shouqiao Hou, Qinglu Zhong, Xiao Hu, Wenbin Liu, Guohui Li, Zhijun Liu, Lin He, Jiajie Diao, Zheng-Jiang Zhu, Dan Li*, Cong Liu*. Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly. Nat Commun. 2020 Mar 24;11(1):1531. doi: 10.1038/s41467-020-15270-4.

58. Yunpeng Sun#, Shouqiao Hou#, Kun Zhao#, Houfang Long, Zhenying Liu, Jing Gao, Yaoyang Zhang, Xiao-Dong Su, Dan Li*, Cong Liu*. Cryo-EM structure of full-length alpha-synuclein amyloid fibril with Parkinson's disease familial A53T mutation. Cell Res. 2020 Apr;30(4):360-362. doi: 10.1038/s41422-020-0299-4.

59. Dan Li*, Cong Liu*. Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination. Biochemistry. 2020 Feb 11;59(5):639-646. doi: 10.1021/acs.biochem.9b01069. (Invited review)

2019年

60. Heng Zhou#, Feng Luo#, Zhipu Luo#, Dan Li, Cong Liu*, Xueming Li*. Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules. Anal Chem, 2019 Sep 3;91(17):10996-11003. doi: 10.1021/acs.analchem.9b01162.

61. Xinrui Gui, Feng Luo, Yichen Li, Heng Zhou, Zhenheng Qin, Zhenying Liu, Jinge Gu, Muyun Xie,, Kun Zhao, Bin Dai, Woo Shik Shin, Jianhua He, Lin He, Lin Jiang, Minglei Zhao, Bo Sun, Xueming Li, Cong Liu*, Dan Li*. Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun, 2019 May 1;10(1):2006. doi: 10.1038/s41467-019-09902-7.

62. Cong Liu*, Yanshan Fang*. New insights of poly(ADP-ribosylation) in neurodegenerative disease: A focus on protein phase saparation and pathologic aggregation. Biochem Pharmacol, 2019 Sep:167:58-63. doi: 10.1016/j.bcp.2019.04.028. (Invited review)

63. Dongfei Ma, Chunhua Xu, Wenqing Hou, Chunyu Zhao, Jianbing Ma, Xingyuan Huang, Qi Jia, Lu Ma, Jiajie Diao, Cong Liu*, Ming Li*, Ying Lu*. Detecting single molecule dynamics on lipid membranes with quenchers-in-a-liposome FRET. Angew Chem Int Ed Engl, 2019 Apr 16; 58(17):5577-5581. doi: 10.1002/anie.201813888.

64. Yongjia Duan, Aiying Du, Jinge Gu, Gang Duan, Chen Wang, Xinrui Gui, Zhiwei Ma, Beituo Qian, Xue Deng, Kai Zhang, Le Sun, Kuili Tian, Yaoyang Zhang, Hong Jiang, Cong Liu*, Yanshan Fang*. PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins. Cell Res, 2019 Mar;29(3): p. 233-247. doi: 10.1038/s41422-019-0141-z. 

65. Xiang Zhang, Shengnan Zhang, Li Zhang, Jinxia Lu, Chunyu Zhao, Feng Luo, Dan Li, Xueming Li*, Cong Liu*. Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity. J Biol Chem, 2019 Mar 29;294(13):4956-4965. doi: 10.1074/jbc.RA118.005980. 

2018年

66. Shengnan Zhang#*, Chuchu Wang#, Jinxia Lu, Xiaojuan Ma, Zhenying Liu, Dan Li, Zhijun Liu, Cong Liu*. In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau. Int J Mol Sci. 2018 Dec 26;20(1):90. doi: 10.3390/ijms20010090.

67. Zhenying Liu#, Chuchu Wang#, Yichen Li, Chunyu Zhao, Tongzhou Li, Dan Li, Shengnan Zhang*, Cong Liu*. Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization. J Biol Chem. 2018 Sep 21;293(38):14880-14890. doi: 10.1074/jbc.RA118.004034.

68. Yaowang Li#, Chunyu Zhao#, Feng Luo#, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li*, Cong Liu*, Xueming Li*. Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy. Cell Res. 2018 Sep;28(9):897-903. doi: 10.1038/s41422-018-0075-x.

69. Dan Li*, Cong Liu*. Better Together: A Hybrid Amyloid Signals Necroptosis. Cell. 2018 May 17;173(5):1068-1070.  doi: 10.1016/j.cell.2018.04.030. (Invited comment)

70. Feng Luo#, Xinrui Gui#, Heng Zhou#, Jinge Gu, Yichen Li, Xiangyu Liu, Minglei Zhao, Dan Li*, Xueming Li*, Cong Liu*. Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat Struct Mol Biol. 2018 Apr;25(4):341-346. doi: 10.1038/s41594-018-0050-8.

2017年

71. Jingjing Xie#, Xiaojia Si#, Shoulai Gu, Mingliang Wang, Jian Shen, Haoyan Li, Jian Shen, Dan Li, Yanjia Fang, Cong Liu*, Jidong Zhu*. Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment. J Med Chem. 2017 Dec 28;60(24):10205-10219. doi: 10.1021/acs.jmedchem.7b01520.

72. Zhenying Liu#, Shengnan Zhang#, Dan Li, Cong Liu*. A Structural View of aB-crystallin Assembly and Amyloid Aggregation. Protein & Peptide Letters. 2017, 24, 1-7.

2016年

73. Chuchu Wang, Chunyu Zhao, Dan Li, Zhiqi Tian, Ying Lai, Jiajie Diao*, Cong Liu*. Versatile Structures of α-Synuclein. Front Mol Neurosci. 2016 Jun 20;9:48. doi: 10.3389/fnmol.2016.00048. 

74. Guang Yang, Xiang Zhang, Zdravko Kochovski, Yufei Zhang, Bin Dai, Fuji Sakai, Lin Jiang, Yan Lu, Matthias Ballauff, Xueming Li, Cong Liu*, Guosong Chen*, Ming Jiang. Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions. J Am Chem Soc. 2016 Feb 17;138(6):1932-7. doi: 10.1021/jacs.5b11733.

2015年

75. Bin Dai#, Dan Li#, Wenhui Xi, Fang Luo, Xiang Zhang, Man Zou, Mi Cao, Jun Hu, Wenyuan Wang, Guanghong Wei*, Yi Zhang*, Cong Liu*. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2996-3001. doi: 10.1073/pnas.1416690112.