副研究员
张胜男
职  称: 副研究员
学  历: 博士研究生
电  话: 021-68582589
职  务:
传  真:
电子邮件: zhangshengnan@sioc.ac.cn
个人网页:
通信地址: 上海市浦东新区张江高科技园区海科路100号13号楼
个人简历

2000.09-2004.07   北京大学,化学与分子工程学院,学士

2004.09-2011.05   北京大学,化学与分子工程学院,博士,导师:夏斌

2011.09-2016.05   美国得克萨斯大学健康与科学医学中心,博士后,合作导师:Paul Fitzpatrick

2016.06-至今      中国科学院上海有机化学研究所,副研究员

 

研究方向
张胜男副研究员一直从事与人类疾病相关的重要蛋白的结构与分子机制的研究,主要发展和运用多种生物化学的技术手段,如核磁共振等来研究与神经退行性疾病密切相关的重要淀粉样蛋白和分子伴侣蛋白相互作用的分子机制和病理毒性。
社会任职
 
获奖及荣誉
代表论著

1 Zhang, Shengnan; Liu, Yu-Qing; Jia, Chunyu; Lim, Yeh-Jun; Feng, Guoqin; Xu, Enquan; Long, Houfang; Kimura, Yasuyoshi; Tao, Youqi; Zhao, Chunyu; Wang, Chuchu; Liu, Zhenying; Hu, Jin-Jian; Ma, Meng-Rong; Liu, Zhijun; Jiang, Lin; Li, Dan; Wang, Renxiao; Dawson, Valina L; Dawson, Ted M; Li, Yan-Mei; Mao, Xiaobo; Liu, Cong ; Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease., Proceedings of the National Academy of Sciences, 2021, 118(26)      

2 Liu, Zhenying; Zhang, Shengnan; Gu, Jinge; Tong, Yilun; Li, Yichen; Gui, Xinrui; Long, Houfang; Wang, Chuchu; Zhao, Chunyu; Lu, Jinxia; He, Lin; Li, Ying; Liu, Zhijun; Li, Dan; Liu, Cong ; Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation., Nat Struct Mol Biol, 2020, 27(4): 363-372      

3 Jia, Chunyu; Ma, Xiaojuan; Liu, Zhenying; Gu, Jinge; Zhang, Xiang; Li, Dan; Zhang, Shengnan ; Different Heat Shock Proteins Bind alpha-Synuclein With Distinct Mechanisms and Synergistically Prevent Its Amyloid Aggregation, Frontiers in Neuroscience, 2019, 13: 0-1124    

4 Zhang, Shengnan; Wang, Chuchu; Lu, Jinxia; Ma, Xiaojuan; Liu, Zhenying; Li, Dan; Liu, Zhijun; Liu, Cong ; In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau, International Journal of Molecular Sciences, 2019, 20(1): 0-90      

5Liu Zhenying; Wang Chuchu; Li Yichen; Zhao Chunyu; Li Tongzhou; Li Dan; Zhang Shengnan; Liu Cong ; Mechanistic insights into the switch of alpha B-crystallin chaperone activity and self-multimerization, Journal of Biological Chemistry, 2018, 293(38): 14880-14890     

承担科研项目情况