教育经历
2004.09-2011.07 中国科学技术大学分子生物学与细胞生物学 博士
2000.09-2004.06 中国科学技术大学生命科学学院 学士
工作经历
2016.09-至今 中国科学院上海有机化学研究所 副研究员
2012.09-2016.08 中国科学院上海有机化学研究所 助理研究员
2011.08-2012.08 香港科技大学大学医学院 博士后
综合利用X射线晶体衍射、溶液核磁共振、冷冻电镜以及分子生物学等手段研究蛋白质结构与功能,阐释蛋白质之间以及蛋白质与小分子化合物之间的相互作用机制。特别关注RIPK1激酶在TNFa通路中的复合物的调控机制。
Journal papers
[1] Jianping Liu, Lifeng Pan*, Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain, Biochim Biophys Acta Mol Cell Res., 2018 Jul 5;1865(10):1410-1422.
[2] Jianping Liu, Yingli Wang, Yukang Gong, Tao Fu, Shichen Hu, Zixuan Zhou, Lifeng Pan*, Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly, Cell Reports, 2017, 21(1):27-36.
[3] Jianping Liu, Jiahai Zhang, Qingguo Gong, Peng Xiong, Hongda Huang, Bo Wu, Guowei Lu, Jihui Wu* and Yunyu Shi*, Solution structure of tandem SH2 Domains from Spt6 protein and their binding to the phosphorylated RNA polymerase II C-terminal domain, Journal of Biological Chemistry, 2011, 286(33): 29218-29226
[4] Daichao Xu#, Jianping Liu#,Tao Fu, Bing Shan, Lihui Qian, Lifeng Pan*, and Junying Yuan*, USP25 Regulates Wnt Signaling by Controlling the Stability of Tankyrases, Genes & Development, 2017, 31: 1024-1035.
[5] Hengyue Shan#, Jianping Liu#, Jiali Shen#, Jialin Dai#, Gang Xu#, Kuankuan Lu, Chao Han, Yaru Wang,Xiaolong Xu,Yilun Tong,Huaijiang Xiang,Zhiyuan Ai,Guanglei Zhuang,Junhao Hu,Zheng Zhang, Ying Li, Lifeng Pan* and Li Tan*, Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chemical Biology, 2020, 28(6): 855-865.e9
Book chapter
[1] Jianping Liu, Ying Li, Lifeng Pan, Structural Basis of Autophagy Regulatory Proteins, Advances in Experimental Medicine and Biology, 2019, 1206:287-326. (invited book chapter review).