Radical Alliances. Solutions and Opportunities for Organic Synthesis
时间:4月19日(星期五)上午10:00
地点:君谋楼一楼 报告厅
PIFI 2024 Distinguished Scientist LectureRadical Alliances.Solutions and Opportunities for Organic SynthesisProf. Samir Z. ZardLaboratoire de Synthèse OrganiqueEcole Polytechnique,France 主持人:李超忠 研究员时 间:2024年4月19日(星期五)上午10:00地 点:君谋楼一楼 报告厅 欢迎听讲!【Abstract】We have shown that xanthates and related thiocarbonylthio derivatives allow the generation of radicals under conditions where the radicals possess a considerably increased effective lifetime even in a concentrated medium. Intermolecular additions to un-activated alkenes,as well as a variety of reputedly difficult radical transformations can now be easily accomplished. No metals,heavy or otherwise,are required,and the starting materials and reagents are cheap and readily available. Complex,densely functionalized structures can be constructed in a convergent,modular fashion. In the course of our study of the scope and limitations of this chemistry,we have uncovered a few surprising transformations. Recent results and some mechanistic aspects will be presented and discussed briefly.