研究员
欧阳瑶
职  称: 研究员
学  历: 博士研究生
电  话:
职  务: 课题组长
传  真:
电子邮件: ouyangy@sioc.ac.cn
个人网页:
通信地址: 上海市零陵路345号
个人简历

2012.09–2016.06 中国药科大学 药学(国家生命科学与技术人才培养基地班)本科

2016.09–2021.06 中国科学院上海有机化学研究所博士研究生(导师:卿凤翎)

2021.10–2023.06 康奈尔大学和普林斯顿大学博士后(导师:Todd K. Hyster)

2023.06-2026.05 伊利诺伊大学厄巴纳-香槟分校和霍华德·休斯医学研究所 (导师:Wilfred van der Donk)

2026.05–至今    中国科学院上海有机化学研究所 研究员

研究方向

(1)生物催化;(2)生物工程:环肽展示和大环肽从头发现;(3)天然产物生物合成

社会任职
获奖及荣誉

2021 中国科学院大学优秀毕业生

2021 中国科学院大学院长优秀奖

2020 中国科学院唐立新奖学金

2020 研究生国家奖学金

2019 中国科学院大学优秀学生

代表论著

1. Ouyang, Y*#.; Nadeem,H.#; Shukla, D.*; van der Donk, W. A*. In preparation

2. Ouyang, Y.; Yu, Y.; Zhu, L.-Y.; Nguyen, D. T.; van der Donk, W. A*. Oxidative Peptide Backbone Cleavage by a HEXXH Enzyme During RiPP Biosynthesis. J. Am. Chem. Soc. 2026, 148, 3551.

3. Ouyang, Y.#;Wang, S.#; Sorigue, D.; Hyster, T. K*. Nucleophilic α-Functionalization of Benzyl Amines Using an Engineered Threonine Aldolase. J. Am. Chem. Soc. 2025, 147, 25184.

4. Liu, S.; Zhou, J.; Yu, L.; Liu, Y.; Huang, Y.*; Ouyang, Y.*; Liu, G.-K.*; Xu, X.-H.*; Shibata, N*. Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications. Chem. Rev.2025, 125, 4603.

5. Ouyang, Y.#;Page, C. G.#; Bilodea, C.#; Hyster, T. K*. Synergistic Photoenzymatic Catalysis Enables Synthesis of α-Tertiary Amino Acids Using Threonine Aldolases.J. Am. Chem. Soc. 2024, 146, 13754.

6. Ouyang, Y.;Qing, F.-L*. Photoredox Catalyzed Radical Fluoroalkylation with Non-Classical Fluorinated Reagents. J. Org. Chem. 2024, 89, 2815.

7. Ouyang, Y.; Turek-Herman, J.; Qiao, T.; Hyster, T. K*. Asymmetric Carbohydroxylation of Alkenes Using Photoenzymatic Catalysis. J. Am. Chem. Soc. 2023, 145, 17018.

8. Emmanuel, M. A.; Bender, S. G.; Bilodeau, C.; Carceller, J. M.; DeHovitz, J. S.; Fu, H.; Liu, Y.; Nicholls, B. T.; Ouyang, Y.; Page, C. G.; Qiao, T.; Raps, F. C.; Sorigué, D. R.; Sun, S.; Turek-Herman, J.; Ye, Y.; Rivas-Souchet, A.; Cao, J.; Hyster, T. K*. Photobiocatalytic Strategies for Organic Synthesis. Chem. Rev.2023, 123, 5459.

9. Ouyang, Y.; Xu, X.-H.; Qing, F.-L*. Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen. Angew. Chem. Int. Ed. 2022, 61, e202114048.

10. Ouyang, Y.; T, C.-L.; Xu, X.-H.; Qing, F.-L*. Copper and Zinc Copromoted Bromo(Chloro)trifluoromethylation of Alkenes and Alkynes with Trifluoromethanesulfonic Anhydride. Org. Lett. 2021, 23, 346.

11. Ouyang, Y.; Xu, X.-H.; Qing, F.-L*. Oxidative Coupling Reactions of Arylboronic Acids and Fluoroform-Derived AgCF3. Chin. J. Org. Chem. 2020, 40, 3426.

12. Ouyang, Y.; Xu, X.-H.; Qing, F.-L*. Hydrotrifluoromethylthiolation of Unactivated Alkenes and Alkynes with Trifluoromethanesulfonic Anhydride through Deoxygenative Reduction and Photoredox Radical Processes. Angew. Chem. Int. Ed. 2019, 58, 18508.

13. Xiang, J.-X.; Ouyang, Y.; Xu, X.-H.; Qing, F.-L*.Argentination of Fluoroform: Preparation of Stable AgCF3 Solution with Diverse Reactivities. Angew. Chem. Int. Ed.2019, 58, 10320. 

14. Ouyang, Y.; Xu, X.-H.; Qing, F.-L*. Trifluoromethanesulfonic Anhydride as a Low-cost and Versatile Trifluoromethylation Reagent. Angew. Chem. Int. Ed. 2018, 57, 6926.

15. Yu, W.; Ouyang,Y.; Xu, X.-H.; Qing, F.-L*. Visible Light-Induced Methoxycarbonyldifluoromethylation of Trimethylsilyl Enol Ethers and Allyltrimethylsilanes with FSO2CF2CO2Me. Chin. J. Chem. 2018, 36, 1024.

Book Chapter:

Ouyang, Y.; Shou, J.-Y.; Qing, F.-L*. Science of Synthesis: Base-Metal Catalysis, Yoshikai, N., Ed.; Thieme: Stuttgart (2022); Vol. 1, p245-324. DOI: 10.1055/sos-SD-238-00130.

(# Contributed equally, *Corresponding author)

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