2006.09–2010.07 四川大学生命科学学院 本科
2010.09–2015.07 清华大学生命科学学院 博士研究生（导师：高宁）
2015.10–2021.02 美国洛克菲勒大学 博士后（合作导师：Thomas Walz）
2021.03–至今 中国科学院上海有机化学研究所 研究员
张一小课题组致力于运用和发展冷冻电镜技术研究富有挑战性的生物学机制问题。其中重点关注细胞对机械力信号的感知和传导机制，创新性的发展了基于纳米磷脂盘和小脂质体的机械力环境模拟方法，首次实现了机械力环境下的电镜三维结构解析。通过对细菌、植物、哺乳动物中不同机械力通道的研究，系统性揭示了脂质及脂质化修饰在机械力感知过程中的重要作用。同时，课题组关注与神经退行疾病及细胞稳态维持相关的重大科学问题，通过结构生物学等手段阐释其分子机制并开发疾病干预手段。相关研究已在Nature (2024, 2021), Science (2023, 2020), Molecular Cell (2025, 2020a, 2020b), Cell Research (2024), Science Advances (2025), Nature Communications (2025, 2024, 2021) 等国际期刊发表多篇高水平论文。
中国电子显微镜学会优秀青年学者奖（2025）
中国科学院优秀导师 （2024）
中国新锐科技人物创新贡献奖 （2024）
中国生物力学与力学生物学十大进展（2024）
上海科技青年35人引领计划 （2022）
上海市海外高层次人才引进计划 （2021）
1. Han, Y., Zhou, Z., Jin, R., Dai, F., Ge, Y., Ju, X., Ma, X., He, S., Yuan, L., Wang, Y., Yang, W., Yue, X., Chen, Z., Sun, Y., Corry, B.# , Cox, C. D.#, and Zhang, Y.# (2024). Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 628, 910–918
Highlithed with Nautre research briefing：Lipids act as structural components of the pore of an ion-channel family. Nature, 10.1038/d41586-024-02477-4
2. Zhou, Z., Ma, X., Lin, Y., Cheng, D., Bavi, N., Secker, G.A., Li, J.V., Janbandhu, V., Sutton, D.L., Scott, H.S., Zhang, Y. #, Cox, C.D.# (2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381, 799-804.
3. Wang, X., Bai, Z., Wallis, C., Wang, H., Han, Y., Jin, R., Lei, M., Yang, T., Gu, C., Jessen, H., Shears, S.#, Sun, Y.#, Corry, B.#, Zhang, Y.# (2025). KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1. Molecular Cell 85, 3209–3224.e3208.
4. Zhou, Z., Dai, F., Cheng, D., Ma, X., Omidkhoda, S. F., Clarke, J., Zhang, H., Laden, M., Guo, Y., Li, J. V., Liu, R., Wong, E. S., Zhang, Y.#, and Cox, C. D.# (2026). MDFIC2 is a sensory neuron–specific PIEZO channel auxiliary subunit. Proc Natl Acad Sci. U.S.A 123, e2530071123. doi:10.1073/pnas.2530071123.
5. Lin, Y., Zhou, Z., Han, Y., Cheng, D., Wang, H., Ju, L. A., Zhang, Y.#, Cox, C. D.#, and Corry, B.# (2026). TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience. Nature Communications.
6. Liu, J., Zhao, J., Gao, J., Zhao, K., Han, Y., Yang, J., Li, Z., Ye, J., Sun, Z., Wang, F., Liu, X., Li, Z., Ji, S., Liu, B., Liu, C., Zhang, Y., Yuan, J.#, and Chou, J. J.# (2026). Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome. Nature 653, 1196–1204. 10.1038/s41586-026-10304-1.
7. Zhang, Y., Daday, C., Gu, R., Cox, C.D., Martinac, B., Groot, B., Walz, T. (2021). Visualizing the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 509-514.
8. Zhang, Y., Angiulli, G., Martinac, B., Cox, C. D., and Walz, T. (2021). Cyclodextrins for structural and functional studies of mechanosensitive channels. J Struct Biol X 5, 100053. 10.1016/j.yjsbx.2021.100053.
9. Sun, Y.*, Zhang, Y.*, Aik, W.S., Yang, X.-C., Marzluff, W.F., Walz, T., Dominski, Z., and Tong, L. (2020). Structure of an active human histone pre-mRNA 3’-end processing machinery. Science 367, 700-703.
10. Zhang, Y.*, Sun, Y.*, Shi, Y., Walz, T., and Tong, L. (2020). Structural Insights into the Human Pre-mRNA 3’-End Processing Machinery. Molecular Cell 77: 800-809.
11. Su, M.*, Zhu, L.*, Zhang, Y.*, Paknejad, N.*, Dey, R., Huang, J., Lee, M.Y., Williams, D., Jordan, K.D., Eng, E.T., Ernst, O.P., Meyerson, J., Hite, R., Walz, T., Liu, W., Huang, X. (2020). Structural basis of the activation of heterotrimeric Gs-protein by isoproterenol-bound b1-adrenergic receptor. Molecular Cell 80:59-71.
12. Zhang, Y., Ma, C., Yuan, Y., Zhu, J., Li, N., Chen, C., Wu, S., Yu, L., Lei, J., and Gao, N. (2014). Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome. Nature Structural & Molecular Biology 21, 1042-1046.
* indicates co-first authors, # indicates co-corresponding authors
科技创新2030-“脑科学与类脑研究”重大项目(青年)
国家相关人才项目
中国科学院上海分院青年英才培育计划
上海求索杰出青年课题组长项目
