研究员
薛小松
职  称: 研究员
学  历: 博士研究生
电  话: 021-54925600
职  务: 课题组长
传  真:
电子邮件: xuexs@sioc.ac.cn
通信地址: 上海市零陵路345号
个人简历
薛小松,国家优青,中科院百人,研究员,博士生导师。2013年博士毕业于南开大学,师从程津培院士,并于同年留校任教。2018年入选“南开大学百名青年学术带头人”计划。2017年9月-2020年8月,加州大学洛杉矶分校(UCLA)访问学者,师从Ken Houk院士。2021年8月加入中国科学院上海有机化学研究所有机氟化学重点实验室,并于同年获得国家优青和中科院率先行动“百人计划”支持。
研究方向
物理有机化学,计算有机化学,有机氟化学,机器学习在有机化学中的应用
社会任职
 
获奖及荣誉

2013 南开大学优秀博士毕业生

2021 国家优秀青年科学基金

代表论著
[1] “Catalyst-Substrate Helical Character Matching Determines the Enantioselectivity in the Ishihara-Type Iodoarenes Catalyzed Asymmetric Kita-Dearomative Spirolactonization” Hanliang Zheng#, Liu Cai#, Ming Pan, Muhammet Uyanik, Kazuaki Ishihara, and Xiao-Song Xue*, J. Am. Chem. Soc. 2023, 145, 7301-7312.
[2]  “Copper-catalysed difluorocarbene transfer enables modular synthesis” Xin Zeng, Yao Li, Qiao-Qiao Min, Xiao-Song Xue*, Xingang Zhang*, Nat. Chem. 2023, DOI: 10.1038/s41557-023-01236-8.
[3] “Copper(I)-Catalyzed Asymmetric Conjugate Addition of 1,4-Dienes to β-Substituted Alkenyl Azaarenes.” Zhi-Zhou Pan#, Deng Pan#, Jia-Heng Li, Xiao-Song Xue*, Liang Yin*, J. Am. Chem. Soc. 2023, 145, 1749-1758.
[4]  “Thioethers as Dichotomous Electrophiles for Site-Selective Silylation via C-S Bond Cleavage” Shuai Chen#, Xueying Guo#, Haoran Hou, Shasha Geng, Zhengli Liu*, Yun He, XiaoSong Xue*, Zhang Feng*, Angew. Chem. Int. Ed. 2023, e202303470.
[5] “Cu/SaBox-Catalyzed Photoinduced Coupling of Acylsilanes with Alkynes” Long Zheng#, Xueying Guo#, Ying-Chao Li, Yichen Wu, Xiao-Song Xue*, Peng Wang*, Angew. Chem. Int. Ed. 2023, e202216373.
[6]  “Light-Induced Divergent Cyanation of Alkynes Enabled by Phosphorus Radicals” Yanyan Zhang, Yunhong Han, Shengqing Zhu*, Feng-Ling Qing, Xiao-Song Xue*, Lingling Chu*, Angew. Chem. Int. Ed. 2022, e202210838.
[7] “Atroposelective Electrophilic Sulfenylation of N-Aryl Aminoqui-none DerivativesCatalyzed by Chiral SPINOL-Derived Sulfide” Deng Zhu#, Lu Yu#, Hui-Yun Luo, Xiao-Song Xue*, Zhi-Min Chen*, Angew. Chem. Int. Ed. 2022, e202211782.
[8] “Metal-Free Electrochemical Carboxylation of Organic Halides in the Presence of Catalytic Amounts of an Organomediator” Yanwei Wang, Zhiwei Zhao, Deng Pan, Siyi Wang, Kangping Jia, Dengke Ma, Guoqing Yang, Xiao-Song Xue*, Youai Qiu*, Angew. Chem. Int. Ed. 2022, e202210201.
[9] “Low-temperature mineralization of perfluorocarboxylic acids” Brittany Trang#, Yuli Li#, Xiao-Song Xue, Mohamed Ateia, K. N. Houk*, William R. Dichtel1*, Science 2022, 377, 839-845.
[10] “Construction of Complex Macromulticyclic Peptides via Stitching with Formaldehyde and Guanidine” Bo Li#, Zhao Wan#, Hanliang Zheng, Shaokun Cai, Han-Wen Tian, Hong Tang, Xin Chu, Gang He, Dong-Sheng Guo, Xiao-Song Xue*, Gong Chen*, J. Am. Chem. Soc. 2022, 144, 10080-10090.
[11] “Metal-Free C-H Functionalization via Diaryliodonium Salts with a Chemically Robust Dummy Ligand” Yixuan Chen#,Yuefei Gu#, Huan Meng#, Qianzhen Shao#, Zhenchuang Xu, Wenjing Bao, Yucheng Gu, Xiao-Song Xue*, Yanchuan Zhao*, Angew. Chem. Int. Ed. 2022, 61, e2022012.
[12] “Harnessing Natural Products by a Pharmacophore-Oriented Semisynthesis Approach for the Discovery of Potential Anti-SARS-CoV-2 Agents” Yuan-Fei Zhou#, Bing-Chao Yan#, Qian Yang#, Xin-Yan Long#, Dan-Qi Zhang, Rong-Hua Luo, Han-Yu Wang, Han-Dong Sun, Xiao-Song Xue*, Yong-Tang Zheng*, Pema-Tenzin Puno*, Angew. Chem. Int. Ed. 2022, 61, e2022016.
[13]  “Enantioselective Synthesis of Planar-Chiral Macrocycles through Asymmetric Electrophilic Aromatic Amination” Donglei Wang#, Ying-Bo Shao#, Yunrong Chen, Xiao-Song Xue*, Xiaoyu Yang*. Angew. Chem. Int. Ed. 2022, 61, e2022010.
[14] “Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids” Yantao Li, Qianzhen Shao, Hengchi He, Chengjian Zhu*, Xiao-Song Xue*, Jin Xie*, Nat. Commun. 2022, 13, 10.
[15] “Highly γ‐Selective Arylation and Carbonylative Arylation of 3‐Bromo‐3,3‐difluoropropene via Nickel Catalysis.” Ran Cheng, Yueqian Sang, Xing Gao, Shu Zhang, Xiao-Song Xue*, Xingang Zhang*, Angew. Chem. Int. Ed. 2021, 60, 12386-12391.
[16]  “The Acidities of Nucleophilic Monofluoromethylation Reagents: An Anomalous α‐Fluorine Effect.” Hanliang Zheng, Zhen Li, Jianfang Jing, Xiao-Song Xue*, Jin-Pei Cheng. Angew. Chem. Int. Ed. 2021, 60, 9401-9406.
[17] “Highly γ‐Selective Arylation and Carbonylative Arylation of 3‐Bromo‐3,3‐difluoropropene via Nickel Catalysis.” Ran Cheng, Yueqian Sang, Xing Gao, Shu Zhang, Xiao-Song Xue*, Xingang Zhang.* Angew. Chem. Int. Ed. 2021, 60, 12386-12391.
[18] “Cleaving arene rings for acyclic alkenylnitrile synthesis.” Xu Qiu, Yueqian Sang, Hao Wu, Xiao-Song Xue, Zixi Yan, Yachong Wang, Zengrui Cheng, Xiaoyang Wang, Hui Tan, Song Song, Guisheng Zhang, Xiaohui Zhang, K. N. Houk*, Ning Jiao*.Nature 2021, 597, 64-69.
[19] “Establishing for Cation and Radical Donor Ability Scales of Electrophilic F, CF3, and SCF3 transfer reagents.” Man Li, Xiao-Song Xue*, Jin-Pei Cheng. Acc. Chem. Res. 2020, 53, 182?197. (Invited review)
[20] “Radical-Mediated CC Cleavage of Unstrained Cycloketones and DFT Study for Unusual Regioselectivity.” Mingyang Wang, Man Li, Shan Yang, Xiao-Song Xue*, Xinxin Wu , Chen Zhu*. Nat. Commun. 2020, 11, 672-678.
[21] “Mechanism and Origins of Enantioselectivities in Spirobiindane-based Hypervalent Iodine(III) Induced Asymmetric Dearomatizing Spirolactonizations.” Hanliang Zheng, Yueqian Sang, K. N. Houk*, Xiao-Song Xue*, Jin-Pei Cheng. J. Am. Chem. Soc. 2019, 141, 16046-16056.
[22] “Nickel-catalyzed intermolecular oxidative Heck arylation driven by transfer hydrogenation.” Honggui Lv, Huiying Kang, Biying Zhou, Xiao-Song Xue,* Keary Engle,* and Dongbing Zhao.* Nat. Commun. 2019, 10, 5025.
[23] “Controllable Catalytic Difluorocarbene Transfer Enables Access to Diversified Fluoroalkylated Arenes.” Xia-Ping Fu#, Xiao-Song Xue#, Xue-Ying Zhang, Yu-Lan Xiao, Shu Zhang, Yin-Long Guo, Xuebing Leng, K. N. Houk*, Xingang Zhang.* Nat. Chem. 2019, 11, 948–956.
[24] “Metal-free Directed C-H Bond Activation and Borylation.” Jiahang Lv, Xiangyang Chen , Xiao-Song Xue , Binlin Zhao , Yue Zhao , Yi Lu , Jing Zhao , Wei-Yin Sun , Yong Liang, K. N. Houk*, Zhuangzhi Shi*. Nature 2019, 575, 336-340.
[25] “Ambimodal Trispericyclic Transition State and Dynamic Control of Periselectivity.”,Xiao-Song Xue#, Cooper S. Jamieson#, Marc Garcia-Borràs#, Xiaofei Dong#, Zhongyue Yang, K. N. Houk. J. Am. Chem. Soc. 2019, 141, 1217-1221.
[26] “Mechanism and Origins of Chemo- and Stereoselectivities of Aryl Iodide-Catalyzed Asymmetric Difluorinations of β-Substituted Styrenes.” Biying. Zhou, Moriana K. Haj, Eric N. Jacobsen, Houk, K. N.,* Xiao-Song Xue*. J. Am. Chem. Soc. 2018, 140, 15206-15218.
[27] “Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents.” Jingjing Zhang; Yang Jin-Dong; Hanliang Zheng; Xiao-Song Xue*, Herbert Mayr;* Jin-Pei Cheng. Angew. Chem. Int. Ed. 2018, 57, 12690-12695.
 
 
 
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