2011.09–2015.06 内蒙古大学生物技术基地专业本科（导师：阿拉坦高勒）
2015.09–2021.12 中国科学院大学细胞生物学专业博士研究生（导师：袁钧瑛）
2022.01–2024.01 中国科学院上海有机化学研究所博士后（合作导师：袁钧瑛）
2024.02–至今 中国科学院上海有机化学研究所 副研究员
孙维敏博士围绕细胞死亡与炎症调控机制开展系统研究，在疾病相关靶点机制解析、小分子先导化合物发现及新型核酸工具分子构建等方面取得多项创新性成果。其研究聚焦于RIPK1激活调控网络、ACOD1免疫代谢通路及ZBP1驱动的细胞死亡与炎症机制，系统建立了涵盖高通量筛选、靶点验证、作用机制解析及体内外功能评价的多层级研究技术体系，为相关疾病的机制研究与药物研发提供了重要理论基础和技术支撑。
1. Sun W#, Wu G, Tian X, Qi C, Liu J, Tong Y, Zhang M, Gao J, Cao Z, Zhang Y, Liu Z, Tian X, Wu P, Peng C, Li J, Tan L, Shan B, Liu J*, Li Y*, Yuan J*, Small Molecule Activator of TAK1 Promotes Its Activity-Dependent Ubiquitination and TRAIL-mediated Tumor Cell Death. Proc. Natl. Acad. Sci. U.S.A. 2023, 120(39).
2. Sun W#, Daichao Xu*, High-Throughput Screening for Cell Death Inducers and Inhibitors. Methods Cell Biol . 2026, 209:173-186.
3. Sun Z, Ye J, Sun W, Jiang L, Shan B, Zhang M, Xu J, Li W, Liu J, Jing H, Zhang T, Hou M, Xie C, Wu R, Pan H, Yuan J. Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis. Nat Commun. 2025 Feb 22;16(1):1890.
4. Cao Z, Min X, Xie X, Huang M, Liu Y, Sun W, Xu G, He M, He K, Li Y, Yuan J. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2320383121.
5. Yang Y, Fang H, Xie Z, Ren F, Yan L, Zhang M, Xu G, Song Z, Chen Z, Sun W, Shan B, Zhu ZJ, Xu D. Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice. Nat Microbiol. 2024 Aug;9(8):2144-2159.
6. Wu G, Li D, Liang W, Sun W, Xie X, Tong Y, Shan B, Zhang M, Lu X, Yuan J*, Li Y*, PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death. Cell Death Dis. 2022, 13(9):773.
7. Xie X, Liu J, Liang W, Zhang Y, Gong X, Yuan S, Qi C, Huang M, Shi L, Hou M, Zhang M, Liu W, Sun W, Wu Y, Li C, Cao Z, Jing H, Qian L, Liu J, Yuan S, Wang Q, Shen Y, Liu Z, Li Y, Pan H, Zhu B, Shan B, He K, Wang W, Zou C, Li Y, Chou JJ, Yuan J. Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors. Immunity. 2026 Feb 10;59(2):419-437.
8. Yuan J, Li Y, Sun W, Tan L, Shan H. Antitumor application of R406 and its derivatives synergizing with TRAIL. CN 2023109496726
国家青年科学基金项目，批准号：22507137；项目名称：乌头酸脱羧酶ACOD1抑制剂的开发与应用研究；资助经费：30万元；项目起止年月：2026年01月至2028年12月。
