Radical-mediated enzymatic carbon chain fragmentation-recombination
Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen & Wen Liu
Published online: 16 January 2011 | doi:10.1038/nchembio.512
Radical SAM enzymes are famous for catalyzing chemically diverse reactions. A mechanistic investigation of NosL, responsible for functionalizing the indole precursor of nosiheptide, now shows that this enzyme catalyzes an unusual fragmentation-recombination reaction that is tolerant to non-natural halogen substitutents.
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