2001-2005 中国科学技术大学生命科学学院 学士

2005-2010 中国科学技术大学生命科学学院 博士

2010.7-2016.1 美国Scripps研究所 博士后

2016.1-至今 中科院上海有机化学研究所 研究员

蛋白质合成与修饰途径的化学生物学，涉及基因转录、蛋白质翻译及翻译后修饰过程的关键因子或酶的分子结构、催化机理、功能调控以及药物筛选等。当前的主要研究对象包括：氨基酰-tRNA合成酶、糖基转移酶、MiTF/TFE家族转录因子等。

2013-2015：PGA-WCAD Postdoctoral Fellowships in Cancer Biology

2010：中国科学技术大学优秀毕业研究生奖学金

2004：中国科学技术大学优秀学生奖学金

2003：中国科学技术大学优秀学生奖学金

2001：中国科学技术大学优秀学生奖学金

1. Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Qiao H, Wang Z, Yang H, Xia M, Yang G, Bai F, Wang J, Fang P. Commun Biol. 2024 Jul 16;7(1):867.

2. Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Zhou J, Xia M, Huang Z, Qiao H, Yang G, Qian Y, Li P, Zhang Z, Gao X, Jiang L, Wang J, Li W, Fang P. Commun Biol. 2024 Jun 18;7(1):742.

3. Trading in catalytic power for sensing. Hei Z, Wang J, Fang P. Structure. 2024 Jun 6;32(6):647-649.

4. Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain. Huang C, Xia M, Qiao H, Liu Z, Lin Y, Sun H, Yu B, Fang P, Wang J. J Biol Chem. 2023 Oct;299(10):105240.

5. Structural Basis of Low-Molecular-Weight Thiol Glycosylation in Lincomycin A Biosynthesis. Dai Y, Cheng Y, Ding W, Qiao H, Zhang D, Zhong G, Xia M, Tao J, Sun P, Fang P, Liu W. ACS Chem Biol. 2023 Jun 16;18(6):1271-1277.

6. Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development. Zeng QY, Zhang F, Zhang JH, Hei Z, Li ZH, Huang MH, Fang P, Wang ED, Sun XJ, Zhou XL. J Biol Chem. 2023 May;299(5):104704.

7. Oxidase Heterotetramer Completes 1-Azabicyclo[3.1.0]hexane Formation with the Association of a Nonribosomal Peptide Synthetase. Cheng Y, Yi X, Zhang Y, He Q, Chen D, Cao W, Fang P, Liu W. J Am Chem Soc. 2023 Apr 26;145(16):8896-8907.

8. Inhibiting autophagy before it starts. Lin Y, Yu B, Fang P, Wang J. Autophagy. 2024 Apr;20(4):923-924.

9. A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Lin Y, Shi Q, Yang G, Shi F, Zhou Y, Wang T, Xu P, Li P, Liu Z, Sun H, Zhao Z, Ding K, Wang Z, Feng H, Yu B, Fang P, Wang J. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2213670120.

10. Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion. Qiao H, Xia M, Cheng Y, Zhou J, Zheng L, Li W, Wang J, Fang P. Commun Biol. 2023 Jan 27;6(1):107.

11. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Liu Z, Chen K, Dai J, Xu P, Sun W, Liu W, Zhao Z, Bennett SP, Li P, Ma T, Lin Y, Kawakami A, Yu J, Wang F, Wang C, Li M, Chase P, Hodder P, Spicer TP, Scampavia L, Cao C, Pan L, Dong J, Chen Y, Yu B, Guo M, Fang P, Fisher DE, Wang J. Cell Res. 2023 Jan;33(1):55-70.

12. Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Liu Y, Chen Y, Jiang J, Chu X, Guo Q, Zhao L, Feng F, Liu W, Zhang X, He S, Yang P, Fang P, Sun H. Eur J Med Chem. 2023 Feb 5;247:115013.

13. Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex. Wu S, Zheng L, Hei Z, Zhou JB, Li G, Li P, Wang J, Ali H, Zhou XL, Wang J, Fang P. Cell Mol Life Sci. 2022 Feb 8;79(2):128.

14. Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor. Zhou J, Huang Z, Zheng L, Hei Z, Wang Z, Yu B, Jiang L, Wang J, Fang P. Nucleic Acids Res. 2020 Nov 18;48(20):11566-11576.

15. Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Zhou J, Zheng L, Hei Z, Li W, Wang J, Yu B, Fang P. ACS Chem Biol. 2020 Apr 17;15(4):1016-1025.

16.Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. Hei Z, Wu S, Liu Z, Wang J, Fang P. J Biol Chem. 2019 Mar 29;294(13):4775-4783.