1990年毕业于陕西师范大学化学系,1990-1996年在中国科学院兰州化学物理研究所攻读分析化学硕士和博士研究生,获理学博士学位。1999年至2010年在比利时Leuven大学药学院做博士后研究,2000年10月至2003年9月在德国Tubingen大学有机化学研究所从事博士后研究。2003年入选中国科学院人才计划任中国科学院上海有机化学研究所研究员,课题组长和博士生导师。2009年至2015年任上海有机所分析化学研究室主任。2015年至今生命有机化学国家重点实验室。中国化学会色谱分析专业委员会委员,《色谱》期刊副主编,《有机化学》,《仪器分析与技术》,《separation》编委。
发展新的分析方法和技术用于抗肿瘤药物的高效筛选,在细胞水平获得活性、选择性和作用靶标谱;通过发展新的基于质谱的多组学分析方法,在研发早期准确评估药物的疗效并预测副作用,降低新药研发失败的风险。
1. 基于色谱-质谱分析的高效率的药物筛选技术
2. 多组学集成解析药物作用靶标和机制
3. 组蛋白和DNA表观遗传化学修饰的小分子调控
1. 中国科学院人才计划资助
2. 2017年中国分析测试协会科学技术一等奖
3. 2019年第21届中国发明专利优秀奖
1. Y. XU, M. M Zheng, L. Gong, G.Z. Liu, S. S. Qian, Y. Han, J.W. Kang, Comprehensive profiling of rapamycin interacting proteins with multiple mass spectrometry-based omics techniques, Anal Chem, 2023, in press.
2. D. Qiu, G. Liu, F. Li, J. Kang, Determination of 5-methyldeoxycytosine and oxidized derivatives by nano-liquid chromatography with zwitterionic monolithic capillary column, J Chromatogr A 1693 (2023) 463895.
3. S. S. Qian, Y. Han, Y. Zhang, Y. Du, J. Li, X. Yang, J. Kang, Discovery of AHCY as an off-target of doxorubicin by integrative analysis of photoaffinity labeling chemoproteomics and untargeted metabolomics, Anal Chem 94(49) (2022) 17121-17130.
4. C. Lou, X. Ye, G. Chen, J. Zhu, J. Kang, Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis, J Chromatogr A 1636 (2021) 461790.
5. G. Liu, T. Fu, Y. Han, S. Hu, X. Zhang, M. Zheng, P. Hao, L. Pan, J. Kang, probing protein–protein interactions with label-free mass spectrometry quantification in combination with affinity purification by spin-tip affinity column, Anal Chem 92(2020) 3913-3922.
6. Y. Zhang, C. Lou, Y. Xu, J. Li, S. Qian, F. Li, J. Kang, screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis, J Chromatogr A (2019) 460625.
7. M. Xu, M. Zheng, G. Liu, M. Zhang, J. Kang, screening of break point cluster region belson tyrosine kinase inhibitors by capillary electrophoresis, J Chromatogr A, 1537 (2018) 128-134.
8. M. Xu, C. Liu, M. Zhou, Q. Li, R. Wang, J. Kang, screening of small-molecule inhibitors of protein–protein interaction with capillary electrophoresis frontal analysis, Anal Chem, 88 (2016) 8050-8057.
9. F. Li, Y. Zhang, D. Qiu, J. Kang, screening of epidermal growth factor receptor inhibitors in natural products by capillary electrophoresis combined with high performance liquid chromatography–tandem mass spectrometry, J Chromatogr A, 1400 (2015) 117-123.
10. Q. Zhang, X. Chen, Z. Zhu, X. Zhan, Y. Wu, L. Song, J. Kang, structural analysis of low molecular weight heparin by ultraperformance size exclusion chromatography/time of flight mass spectrometry and capillary zone electrophoresis, Anal Chem, 85 (2013) 1819-1827.