2001. 9 – 2005. 7 湖北师范大学化学系 学士
2007. 9 – 2012. 7 南开大学药学院 博士
2012. 8 – 2015. 2 佐治亚州立大学化学系 博士后
2015. 4 – 2019. 9 乔治亚大学复杂糖研究中心 博士后
2019. 9 – 至今 中国科学院上海药物研究所，研究员，课题组长，博士生导师
糖链及糖缀合物的合成与功能研究：发展高效的化学合成法和化学酶促合成法，制备结构多样化的复杂糖链及糖缀合物，用于药物先导化合物的筛选，抗感染、抗肿瘤与抗血栓药物的研发。
T. Ogawa Young Investigator Award （2024年）
国家海外高层次青年人才（2022年）
上海市浦江人才（2020）
1. Zhuojia Xu, Yating Liu, Jialin Liu, Wenjing Ma, Zhumin Zhang, Digantkumar G. Chapla, Liuqing Wen, Kelley W. Moremen, Wen Yi, Tiehai Li*. Integrated chemoenzymatic synthesis of a comprehensive sulfated ganglioside glycan library to decipher functional sulfoglycomics and sialoglycomics. Nat. Chem. 2024, 16, 881-892.
2. Tianhui Hao, Ke Feng, Hongzhen Jin, Jiawei Li, Chenkai Zhou, Xingbang Liu, Wei Zhao, Fan Yu*, Tiehai Li*. Acceptor-Reactivity-Controlled Stereoconvergent Synthesis and Immunological Activity of a Unique Pentasaccharide from the Cell Wall Polysaccharide of Cutibacterium acnes C7. Angew. Chem. Int. Ed. 2024, 63, e202405297.
3. Yating Liu, Mengkun Yan, Minghui Wang, Shiwei Luo, Shasha Wang, Yawen Luo, Zhuojia Xu, Wenjing Ma, Liuqing Wen, Tiehai Li*. Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7. ACS Cent. Sci. 2024, 10, 417-425.
4. Jie Zhao, Xinliang Liu, Jialin Liu, Farong Ye, Bingcheng Wei, Minggang Deng, Tiehai Li*, Ping Huang*, Ping Wang*. Chemical Synthesis Creates Single Glycoforms of the Ectodomain of Herpes Simplex Virus-1 Glycoprotein D. J. Am. Chem. Soc. 2024, 146, 2615-2623.
5. Wenjing Ma, Zhuojia Xu, Yuhan Jiang, Jialin Liu, Dandan Xu, Wei Huang, Tiehai Li*. Divergent Enzymatic Assembly of a Comprehensive 64-Membered IgG N-Glycan Library for Functional Glycomics. Adv. Sci. 2023, 10, 2303832.
6. Shiwei Luo, Yating Liu, Tianhui Hao, Wenjing Ma, Yawen Luo, Shasha Wang, Zhuojia Xu, Chaoyu Hu, Liuqing Wen, Tiehai Li*. Chemoenzymatic Total Synthesis of Haemophilus ducreyi Lipooligosaccharide Core Octasaccharides. Org. Lett. 2023, 25, 2312-2317.
7. Wenjing Ma, Yaqi Deng, Zhuojia Xu, Xingbang Liu, Digantkumar G. Chapla, Kelley W. Moremen, Liuqing Wen, Tiehai Li*. Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase. J. Am. Chem. Soc. 2022, 144, 9057-9065.
8. Chaoyu Hu, Shengjie Wu, Fei He, Deqin Cai, Zhuojia Xu, Wenjing Ma, Yating Liu, Bangguo Wei*, Tiehai Li*, Kan Ding*. Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius. Angew. Chem. Int. Ed. 2022, 61, e202202554.
9. Liangwei Zhang, Yating Liu, Zhuojia Xu, Tianhui Hao, Peng George Wang, Wei Zhao, Tiehai Li*. Design and Synthesis of Neutralizable Fondaparinux. JACS Au, 2022, 2, 2791-2799.
10. Zhumin Zhang, Zhuojia Xu, Xingbang Liu, Shiwei Luo, Tiehai Li*. Stereoselective Synthesis of β-C-Glycosides of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) via SmI2-Mediated Reformatsky Reactions. Org. Lett. 2021, 23, 6090-6093.
11. ZhuoJia Xu, Yaqi Deng, Zhumin Zhang, Wenjing Ma, Wanjin Li, Liuqing Wen*, Tiehai Li*. Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans. J. Org. Chem. 2021, 86, 10819-10828.
12. Chengkai Zhou, Zhuojia Xu, Gen Li, Qi Gao, Qiang Sui, Tiehai Li*. Efficient synthesis of monophosphoryl lipid A mimetic RC-529. J. Carbohydr. Chem. 2021, 40, 501-517.
