2006-2010 北京大学化学与分子工程学院 学士
2010-2015 北京大学化学与分子工程学院 博士
2015-2020 美国西北大学 博士后
2020.6-至今 中国科学院上海有机化学研究所 研究员、课题组长
针对生物酶进行设计和应用。一方面,通过对高价值化合物(药物中间体、化妆品功能食品原料)进行酶催化合成路线设计、酶库挖掘和定向进化、发酵放大,实现产业化生产。另一方面,开发生物酶作为药物和保健食品的潜力,并进行设计和优化提高生物酶药物和保健食品的功效。
2021 RSC Horizon Prizes (团队)
2021 高等学校科学研究优秀成果奖(科学技术)一等奖
1. Tongxiao Cui, Yi Man, Feifei Wang, Shuyang Bi, Liang Lin*, Ran Xie*. Glycoenzyme Tool Development: Principles, Screening Methods, and Recent Advances. Chinese Journal of Chemistry 40, 746-758 (2022).
2. Liang Lin#, Weston Kightlinger#, Adam J. Hockenberry, Michael C. Jewett, and Milan Mrksich. Sequential glycosylation of proteins with substrate-specific N-glycosyltransferases. ACS Central Science 6, 144-154 (2020).
3. Weston Kightlinger#, Liang Lin#, Madisen Rosztoczy, Wenhao Li, Matthew P. DeLisa, Milan Mrksich, and Michael C. Jewett. Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases. Nature Chemical Biology, 14, 627-635 (2018).
4. Liang Lin#, Ling Liu#, Bing Zhao, Ran Xie, Wei Lin, He Li, Yaya Li, Minlong Shi, Ye-Guang Chen, Timothy A. Springer, and Xing Chen. Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology 10, 465-471 (2015).
5. Liang Lin#, Xiangdong Tian#, Senlian Hong#, Peng Dai, Qiancheng You, Ruyi Wang, Lianshun Feng, Can Xie, Zhongqun Tian, and Xing Chen. A bioorthogonal Raman reporter strategy for SERS detection of glycans on live cells. Angewandte Chemie International Edition 52, 7266-7271 (2013).
6. Milan Mrksich, Michael C. Jewett, Liang Lin, Weston Kightlinger. USA Patent, 62545760. August 15th, 2017.
7. Michael C. Jewett, Weston Kightlinger, Milan Mrksich, Liang Lin. USA Patent, 63051825. July 14th, 2020.
8. Liang Lin, Long Lv, Yan Jiang, Yaming Wu, Shucheng Song, Lili Sun, Xiaoran Ding. China Patent, ZL201380010573.X. April 26th, 2024.
9. Liang Lin, Ping Wang, Li Li. International Patent, PCT/CN2024/112335. August 9th, 2024.
10. Xing Chen, Zhongqun Tian, Xiangdong Tian, Liang Lin, Senlian Hong. China Patent, ZL201210342478.3. March 26th, 2014.