梅雪锋，美国乔治敦大学（Georgetown University）化学博士。中国科学院上海药物研究所，药物质量控制与固体化学研究中心主任，研究员，课题组长。2006-2010年间就职于美国新泽西州著名制药企业诺华制药公司（美国），担任高级研究员，项目负责人；2010年回国工作，2011年起担任药物质量控制与固态化学研究中心主任；中国药物晶体协会执行委员。主要从事药物固态化学和药物分析化学方面的工作，研究内容涉及药物共结晶的设计与合成研究，药物固态化学表征、成盐和多晶型筛选等方面。

药物固态化学，成盐和多晶型筛选，药物共结晶及药物开发中的质量研究

2008年 获诺华公司“老虎团”成员奖   

2007年 获诺华公司“超越贡献”奖   

2006年 获优秀博士毕业生奖

2010-2014“中科院引进海外杰出人才计划” 中国科学院   

2011-2013“微量药物溶出动力学测试设备” 中国科学院  

2011-2015“抗肿瘤药物早期成药性评价关键技术研究” 科技部重大专项   

2011- 2015“重大新药创制综合性大平台-药物质量研究平台建设” 科技部重大专项  

2013-2016“重力沉降固相分离方法运用于药物制剂中的晶型分析研究”自然科学基金   

2017-2020“药物一致性评价-药物晶型研究” 科技部重大专项

1. Wang, J.-R.; Li, M.; Yu, Q.; Zhang, Z.; Zhu, B.; Qin, W.; Mei, X.* Anisotropic elasticity and plasticity of an organic crystal. Chem. Commun. 2019, 55, (59), 8532-8535.

2. Li, Z.; Li, M.; Peng, B.; Zhu, B.; Wang, J.-R.; Mei, X.* Improving Compliance and Decreasing Drug Accumulation of Diethylstilbestrol through Cocrystallization. Cryst. Growth Des. 2019, 19, (3), 1942-1953.

3. Cheng, L.; Zhu, B.; Ma, X.; Zhang, Z.; Wang, J. R.; Zhang, Q.; Mei, X.* Identification of an Overlooked Halogen-Bond Synthon and Its Application in Designing Fluorescent Materials. Chem. Eur. J. 2019, 25, (26), 6584-6590.

4. Zhu, B.; Fang, X.; Zhang, Q.; Mei, X.* Ren, G., Study of Crystal Structures, Properties, and Form Transformations among a Polymorph, Hydrates, and Solvates of Apatinib. Cryst. Growth Des. 2019, 19, (5), 3060-3069.

5. Peng, B.; Zhang, Z.; Wang, J. R.; Li, M.; Zhang, Q.; Mei, X.* Confocal Raman micro-spectral evidence and physicochemical evaluation of triamterene salts. Analyst 2019, 144, (2), 530-535.

6. Peng, B.; Wang, J.-R.; Mei, X.* Triamterene-furosemide salt: structural aspects and physicochemical evaluation. Acta Cryst. B 2018, 74, (6), 738-741.

7. Li, M.; Li, Z.; Zhang, Q.; Peng, B.; Zhu, B.; Wang, J.-R.; Liu, L.; Mei, X.* Fine-Tuning the Colors of Natural Pigment Emodin with Superior Stability through Cocrystal Engineering. Cryst. Growth Des. 2018, 18, (10), 6123-6132.

8. Wang, F.-Y.; Zhang, Q.; Zhang, Z.; Gong, X.; Wang, J.-R.; Mei, X.* Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals. CrystEngComm 2018, 20, (39), 5945-5948.

9. Zhu, B.; Wang, J.-R.; Zhang, Q.; Li, M.; Guo, C.; Ren, G.; Mei, X.* Stable Cocrystals and Salts of the Antineoplastic Drug Apatinib with Improved Solubility in Aqueous Solution. Cryst. Growth Des. 2018, 18, (8), 4701-4714.

10. Zha, J.; Zhang, Q.; Li, M.; Wang, J.-R.; Mei, X.* Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol. J. Pharm. Sci. 2018, 107, (11), 2860-2868.

11. Bao, J.; Zhang, Z.; Yan, Z.; Wang, J.-R.; Mei, X.* Cocrystallization in vitamin B9 gels to construct stoichiometry-controlled isostructural materials. CrystEngComm 2018, 20, (12), 1644-1648.

12. He, H.; Zhang, Q.; Wang, J.-R.; Mei, X.* Structure, physicochemical properties and pharmacokinetics of resveratrol and piperine cocrystals. CrystEngComm 2017, 19, (41), 6154-6163.

13. Zhu, B.; Zhang, Q.; Ren, G.; Mei, X.* Solid-State Characterization and Insight into Transformations and Stability of Apatinib Mesylate Solvates. Cryst. Growth Des. 2017, 17, (11), 5994-6005.

14. Yu, Q.; Yan, Z.; Bao, J.; Wang, J.-R.; Mei, X.* Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization. Chem. Commun. 2017, 53, (91), 12266-12269.

15. Li, M. Q.; Zhang, Q.; He, H. Y.; Wang, J.-R.; Mei, X.* Vapor triggered fluorescent color changes among solvates of Emodin. J. Mater. Chem. C 2017, 5, (24), 5970-5976.

16. He, H.; Zhang, Q.; Li, M.; Wang, J.-R.; Mei, X.* Modulating the Dissolution and Mechanical Properties of Resveratrol by Cocrystallization. Cryst. Growth Des. 2017, 17, (7), 3989-3996.

17. Wang, J.-R.; Zhu, B.; Zhang, Z.; Bao, J.; Deng, G.; Ding, Q.; Mei, X.* Polymorphism of Triamcinolone Acetonide Acetate and Its Implication for the Morphology Stability of the Finished Drug Product. Cryst. Growth Des. 2017, 17, (6), 3482-3490.

18. Zhu, B.; Zhang, Q.; Wang, J.-R.; Mei, X.* Cocrystals of Baicalein with Higher Solubility and Enhanced Bioavailability. Cryst. Growth Des. 2017, 17, (4), 1893-1901.

19. Zhang, Q.; Jia, L.; Wang, J.-R.; Mei, X.* Absolute asymmetric synthesis of a sanguinarine derivative through crystal-solution interactions. CrystEngComm 2016, 18, (46), 8834-8837.

20. Wang, J.-R.; Bao, J.; Fan, X.; Dai, W.; Mei, X.* pH-switchable vitamin B9 gels for stoichiometry-controlled spherical co-crystallization. Chem. Commun. 2016, 52, (92), 13452-13455.

21. Li, M.; Zhang, Q.; Wang, J. R.; Mei, X.* Mechanochromism triggered fluorescent color switching among polymorphs of a natural fluorescence pigment. Chem. Commun. 2016, 52, (75), 11288-11291.

22. Zhu, B.; Wang, J.-R.; Ren, G.; Mei, X.* Polymorphs and Hydrates of Apatinib Mesylate: Insight into the Crystal Structures, Properties, and Phase Transformations. Cryst. Growth Des. 2016, 16, (11), 6537-6546.

23. Zhu, B.; Wang, J.-R.; Zhang, Q.; Mei, X.* Greener solid-state synthesis: stereo-selective [2 + 2] photodimerization of vitamin K3 controlled by halogen bonding. CrystEngComm 2016, 18, (34), 6327-6330.

24. Zhang, Q.; Mei, X.* Two New Polymorphs of Huperzine A Obtained from Different Dehydration Processes of One Monohydrate. Cryst. Growth Des. 2016, 16, (6), 3535-3542.

25. Wang, J.-R.; Wang, X.; Yang, Y.; Chen, X.; Mei, X.* Solid-state characterization of 17beta-estradiol co-crystals presenting improved dissolution and bioavailability. CrystEngComm 2016, 18, (19), 3498-3505.

26. He, H.; Huang, Y.; Zhang, Q.; Wang, J.-R.; Mei, X.* Zwitterionic Cocrystals of Flavonoids and Proline: Solid-State Characterization, Pharmaceutical Properties, and Pharmacokinetic Performance. Cryst. Growth Des. 2016, 16, (4), 2348-2356.

27. Zhu, B.; Wang, J.-R.; Zhang, Q.; Mei, X.* Improving Dissolution and Photostability of Vitamin K3 via Cocrystallization with Naphthoic Acids and Sulfamerazine. Cryst. Growth Des. 2016, 16, (1), 483-492.

28. Wang, J.-R.; Yu, Q.; Dai, W.; Mei, X.* Drug-drug co-crystallization presents a new opportunity for the development of stable vitamins. Chem. Commun. 2016, 52, (17), 3572-3575.

29. Wang, J.-R.; Zhu, B.; Yu, Q.; Mei, X.* Selective crystallization of vitamin D3 for the preparation of novel conformational polymorphs with distinctive chemical stability. CrystEngComm 2016, 18, (7), 1101-1104.

30. Wang, J.-R.; Zhou, C.; Yu, X.; Mei, X.* Stabilizing vitamin D3 by conformationally selective co-crystallization. Chem. Commun. 2014, 50, (7), 855-858.