1994-1998 北京医科大学（现为北京大学医学部） 学士
1998-2003 中国科学院上海有机化学研究所 博士
2004-2008 美国明尼苏达大学 博士后
2008-2010 美国明尼苏达大学 研究助理教授
2010.10-至今 中国科学院上海药物研究所 研究员
现任中国科学院上海药物研究所课题组长、所级公共技术中心核磁技术服务部首席技术专家。
致力于基于核磁共振技术的蛋白质-蛋白质、蛋白质-小分子相互作用研究，重点围绕与人类疾病相关的蛋白质质量控制相关调控蛋白和底物蛋白开展工作，探索阐明分子伴侣Hsp90、去泛素化酶USP20、USP25和USP28等的功能调控分子机制和结构基础；发现靶向Hsp90和USP28、USP25、USP2等的抑制剂和变构调节剂，并在分子和细胞水平阐明它们的效应机制；发现靶向淀粉样蛋白异常聚集（Aβ、α-synuclein等）的小分子化学伴侣并解析它们的效应机制等。
上海浦东新区“明珠工程师”（2023年）
明尼苏达大学Paul D. Boyer & James B. Peter Award（2008年）
美国癌症研究学会Scholar-In-Training Award（2006年）
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2. Xu, Z.#, Wang, H.#, Meng, Q., Ding, Y., Zhu, M., Zhou, H., Zhang, N.*, Shi, L.*, Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines, Biochemical Pharmacology, 215, 115746, 2023.
3. Tang, J., Hu, H., Zhou, C.*, Zhang, N.*, Human Aha1's N-terminal extension confers it holdase activity in vitro, Protein Science, 32(9), e4735, 2023.
4. Gao, J.#, Zhou, C.#, Zhong, Y.#, Shi, L., Luo, X., Su, H., Li, M., Xu, Y., Zhang, N.*, Zhou, H.*, Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, Biochemical Pharmacology, 207, 115376, 2023.
5. Zhu, M., Wang, H., Ding, Y., Yang, Y., Xu, Z., Shi, L.*, Zhang, N.*, Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1, FASEB Journal, 36(5), e22329, 2022.
6. Wang, H., Meng, Q., Ding, Y., Xiong, M., Zhu, M., Yang, Y., Su, H., Gu, L., Xu, Y., Shi, L.*, Zhou, H.*, Zhang, N.*, USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines, FEBS Journal, 288(4), 1325-1342, 2021.
7. Zhou, C.#, Zhang, C.#, Zhu, H.#, Liu, Z., Su, H., Zhang, X., Chen, T., Zhong, Y., Hu, H., Xiong, M., Zhou, H., Xu, Y.*, Zhang, A.*, Zhang, N.*, Allosteric Regulation of Hsp90α's Activity by Small Molecules Targeting the Middle Domain of the Chaperone, iScience, 23(2), 100857, 2020.
8. Yang, Y., Ding, Y., Zhou, C., Wen, Y., Zhang, N.*, Structural and Functional Studies of USP20 ZnF-UBP Domain by NMR, Protein Science, 28(9), 1606-1619, 2019.
9. Yang, Y.#, Shi, L.#, Ding, Y., Shi, Y., Hu, H., Wen, Y.*, Zhang, N.*, Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25, Biophysical Journal, 112(10), 2099-2108, 2017.
10. Yu, J.#, Chen, T.#, Zhou, C.#, Lian, F., Tang, X., Wen, Y., Shen, J., Xu, Y., Xiong, B.*, Zhang, N.*, NMR-based Platform for Fragment-Based Lead Discovery Used in Screening BRD4-targeted Compounds, Acta Pharmacologica Sinica, 37(7), 984-93, 2016.
11. Wen, Y.#, Shi, L.#, Ding, Y., Cui, R., He, W.T., Hu, H.*, Zhang, N.*, The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights, Biochemical Journal, 471(2), 155-65, 2015.
12. Zhang, N.#, Wang, Q.#, Ehlinger, A.#, Randles, L.#, Lary, J.W., Kang, Y., Haririnia, A., Storaska, A.J., Cole, J.L., Fushman, D., Walters, K.J.*, Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13, Molecular Cell, 35(3), 280-290, 2009.
13. Husnjak, K.#, Elsasser, S.#, Zhang, N.#, Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K.J.*, Finley, D.*, Dikic, I.*, Proteasome subunit Rpn13 is a novel ubiquitin receptor, Nature, 453(7194), 481-488, 2008.
