2006年9月-2010年6月 四川大学生物学基地班 学士
2010年9月-2015年7月 清华大学生命学院 博士
2015年10月-2020年10月 美国洛克菲勒大学 博士后
2020年10月-2021年3月 美国洛克菲勒大学 助理研究员
2021年3月至今 中国科学院生物与化学交叉研究中心 研究员、课题组长
张一小课题组致力于运用冷冻电镜技术研究富有挑战性的生物学机制问题。蛋白质、核酸、脂类等生物大分子是体内各种生命活动的主要参与者，他们在体内精密协同，执行各种不同的生理功能。结构生物学的研究通过解析这些生物大分子精细的三维结构，阐释它们发挥功能的分子机制，并为相关药物的研发和疾病的治疗提供基础。冷冻电镜技术在近十年来发展十分迅速，已成为生物大分子结构解析的主要手段。本课题组将综合利用冷冻电镜技术、生物化学、细胞生物学、神经生物学等手段研究重要生物大分子的结构与功能。
主要研究方向包括：
（1）与触觉、听觉等感知觉形成相关的机械力通道机制研究
（2）与神经退行疾病相关的生物大分子复合物结构与功能研究
（3）X染色体失活机制研究
1. “科技创新2030-脑科学与类脑研究”青年项目,主持,2022
2. “上海科技青年35人引领计划”，2022
3. “国家优青项目(海外)”,2021
4. 上海脑科学中心“求索杰出青年”课题组长,2021
5. 中科院上海分院“青年英才培育计划”,2021
6. “上海市海外高层次人才引进计划”,2021
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