February 8,2024

Congrats to Hongda Chen et al. for the latest publication in J. Am. Chem. Soc. We have developed a three-component coupling of terminal alkynes, diazo esters, and allylic compounds by novel Rh−Cu cooperative catalysis under mild conditions, leading to quick access to a variety of 1,5-enynes with all−carbon quaternary centers or an unprecedented acylation−allylation of carbene via a Meyer−Schuster rearrangement while using propargylic alcohols. Mechanism studies disclosed the CuCl precursor may aggerate to Cu clusters and nanoparticles (NPs), and the Rh(II) dimer may dissociate to monomeric species, wherein a Cu NPs-catalyzed alkynylation of carbenes may work in cooperation with a dirhodium(II) or Rh(I)-catalyzed allylic alkylation.