June 28，2024

Congrats to Jian Yao et al. for the latest publication in Sci. China Chem. We report an asymmetric Pd/Ag dual metal catalytic system for the non-directed, site- and enantioselective domino Heck/intermolecular C−H functionalization of arenes. Mechanistic studies showed that Pd and Ag act in cooperation in the catalysis and the chiral bisphosphine ligand plays a bifunctional role, i.e., assisting the silver species in the cleavage of the aryl C−H bond, while inducing the enantioselectivity on direct complexation with palladium.