研究员--中国科学院上海有机化学研究所

联系我们

邮箱登陆

English version

中国科学院

内网入口

所内协同办公网入口

研究队伍

	· 院士专家
	· 研究员
	· 千人计划
	· 杰出青年
	· 百人计划
	· 副研究员
	· 人才招聘

您的位置：首页 >研究队伍>人才

姓名:	王震	性别:	男
职称:	研究员	学历:	博士研究生
电话:	021-54925298	传真:
电子邮件:	wangz@sioc.ac.cn	个人主页:
通讯地址:	上海市零陵路345号　200032

简历：

2007年9月-2011年7月合肥工业大学本科

2011年9月-2016年7月中科院广州生物医药与健康研究院博士（导师：丁克）

2016年8月-2021年5月美国H. Lee Moffitt Cancer Center & Research Institute 博士后（导师：季海涛）

2021年6月-至今中科院上海有机化学研究所研究员

研究方向：

激酶抑制剂

激酶非催化功能发现和小分子调控

专家类别：

研究员

职务：

社会任职：

获奖及荣誉：

代表论著：

1. Zhen Wang^#; Min Zhang^#; Victor Quereda^#; Sylvia M. Frydman; Qianqian Ming; Vincent C. Luca; Derek R. Duckett^*; Haitao Ji^*. Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interaction. J. Med. Chem. 2016, 59, 1078–1101.

2. Zhen Wang^#; Min Zhang^#; Wen Luo; Yongqiang Zhang; Haitao Ji^*. Discovery of 2-(3-(3-Carbamoylpi peridin-1–yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein？Protein Interaction. J. Med. Chem. 2021, 64, 5886–5904.

3. Zhen Wang^#; Zilu Li^#; Haitao Ji^*. Direct Targeting of β‐Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives. Med. Res. Rev. 2021, 41, 2109-2129.

4. Qiuju Xun^#; Zhen Wang^#; Xianglong Hu; Ke Ding^*; Xiaoyun Lu^*. Small Molecule CSF1R Inhibitors as Anticancer Agents. Curr. Med. Chem. 2020, 27, 3944-3966.

5. Zhen Wang^#; Min Zhang^#; Jin Wang; Haitao Ji^*. Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein？Protein Interaction. J. Med. Chem. 2019, 62, 3617-3635.

6. Zhen Wang^#; Yali Zhang^#; Daniel M. Pinkas^#; Alice E. Fox; Jinfeng Luo; Huocong Huang; Shengyang Cui; Qiuping Xiang; Tingting Xu; Qiuju Xun; Dongsheng Zhu; Zhengchao Tu; Xiaomei Ren; Rolf A. Brekken; Alex N. Bullock; Guang Liang^*; Ke Ding^*; Xiaoyun Lu^*. Design, Synthesis and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as Dual Inhibitors of Discoidin Domain Receptor 1 and 2 (DDR1/2). J. Med. Chem. 2018, 61, 7977-7990.

7. Min Zhang^#; Zhen Wang^#; Yongqiang Zhang; Wenxing Guo; Haitao Ji^*. Structure-Based Optimization of Small-Molecule Inhibitors for the β-Catenin/B Cell Lymphoma 9 Protein–Protein Interaction. J. Med. Chem. 2018, 61, 2989-3007.

8. Zhen Wang^#; Yali Zhang^#; Sergio G. Bartual; Jinfeng Luo; Tingting Xu; Wenting Du; Qiuju Xun; Zhengchao Tu; Rolf A. Brekken; Xiaomei Ren; Alex N. Bullock^*; Guang Liang^*; Xiaoyun Lu^*; Ke Ding^*. Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Med. Chem. Lett., 2017, 8, 327-332.

9. Zhen Wang^#; Huan Bian^#; Sergio G. Bartual^#; Wenting Du; Jinfeng Luo; Hu Zhao; Shasha Zhang; Cheng Mo; Yang Zhou; Yong Xu; Zhengchao Tu; Xiaomei Ren; Xiaoyun Lu; Rolf A. Brekken; Libo Yao; Alex N. Bullock^*; Jin Su^*; Ke Ding^*. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem., 2016, 59, 5911-5916. (Cover paper)