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李学臣近年代表论著

发布时间:2023-05-16
  1. Chemical synthesis of proteins with base-labile posttranslational modifications enabled by a Boc-SPPS based general strategy towards peptide C-terminal salicylaldehyde esters. Ma, W.; Wu, H.; Liu, S.; Wei, T.; Li, X. D.; Liu, H.*; Li, X.* Angew. Chem. Int. Ed. 2023. (hot paper), 62, e202214053.
  2. Ligation Embedding Aggregation Disruptor Strategy Enables the Chemical Synthesis of PD-1 Immunoglobulin and Extracellular Domains. Wu, H.; Wei, Tong.; Ngai, W. L.; Zhou, H. Y.; Li, X.* J. Am. Chem. Soc. 2022, 144, 14748. 
  3. Superfast Desulfurization for Protein Chemical Synthesis and Modification. Sun, Z.; Ma, W.; Cao, Y.; Wei, T.; Mo, X.; Chow, H. Y.; Tan, Y.; Cheung, C.; Liu, J.; Lee, H. K.; Tse, E. C. M.; Liu, H.; Li, X.*Chem. 2022, 8, 2542. 
  4. Total synthesis of mannopeptimycin β via βhydroxyenduracididine ligation. Wang, J.; Lin, D.; Liu, M.; Liu, H.; Li, X.* J. Am. Chem. Soc. 2021, 143, 12784. 
  5. Chemical Synthesis and Biological Evaluation of Adiponectin Collagenous Domain Glycoforms. Wu, H.; Zhang, Y.; Li, Y.; Xu, J.; Wang, Y.*; Li, X.* J. Am. Chem. Soc. 2021, 143, 7808-7818.  
  6. Synthetic pseudaminic-acid-based antibacterial vaccines confers effective protection against Acinetobacter baumannii infection.. Wei, R.; Yang, X.; Liu, H.; Wei, T.; Chen, S.;* Li, X.* ACS Cent. Sci. 2021, 7, 1535.
  7. Methylation of daptomycin leading to the discovery of kynomycin, a cyclic lipodepsidepeptide active against resistant pathogens. Chow, H. Y.; Po, K. H. L.; Gao, P.; Blasco, P.; Wang, X.; Li, C; Ye, L.; Jin, K.; Chen, K.; Chan, E. W. C.; You, X.; Kao, R. Y. T.; Chen, S.; Li, X.* J. Med. Chem. 2020, 63, 3161.  
  8. Cysteine/Penicillamine ligation independent of terminal steric demands for protein chemical synthesis. Tan, Y.; Li, J.; Jin, K.; Liu, J.; Chen, Z.; Yang, J.; Li, X.* Angew. Chem. Int. Ed. 2020, 59, 12741.  
  9. Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation Mediated Cyclization and Absolute Structure Establishment. Sun, Z.; Shang, Z.; Forelli, N.; Po, K. H. Y.; Chen, S.; Brady, S. F.*; Li X.* Angew. Chem. Int. Ed. 2020, 15, 19868- 19872.  
  10. Chemical protein synthesis: advances, challenges and outlooks. Tan, Y.; Wei, T.; Wu, H. Li, X.* J. Am. Chem. Soc. 2020, 142, 20288.
  11. Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides. Zhang, Y.; Zhang, Q.; Wong, C.; Li, X.* J. Am. Chem. Soc. 2019, 141, 12274-12279.
  12. Serine/Threonine Ligation: Origin, Mechanistic Aspects and Applications. Liu, H.; Li, X.* Acc. Chem. Res. 2018, 51, 1643.
  13. Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de novo Synthesis of Pseudaminic acid. Liu, H.; Zhang, Y.; Wei, R.; Andolina, G.; Li, X.* J. Am. Chem. Soc. 2017, 139, 13420. 
  14. Total synthesis of teixobactin. Jin, K.; Sam, I. H.; Po, K. H. L.; Lin, D.; Ghazvini Zadeh, E. H.; Chen, S.*; Yuan, Y.*; Li, X.* Nature Commun. 2016, 7, 12394.
  15. Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches. Lee, C. L.; Liu, H.; Wong, C.; Chow, H. Y.; Li, X.* J. Am. Chem. Soc. 2016, 138, 10477.
  16. Protein chemical synthesis by serine and threonine ligation. Zhang, Y.; Xu, C.; Lam, H. Y.; Lee, C. L; Li, X.* Proc. Natl. Acad. Sci. USA, 2013, 110, 6657.  
  17. Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation. Lam, H. Y.; Zhang, Y.; Liu, H.; Xu, J.; Wong, C. T.; Xu, C.; Li, X.* J. Am. Chem. Soc. 2013, 135, 6272.  
  18. Synthesis of Constrained Head-to-Tail Cyclic Tetrapeptides by an Imine-induced Ring Closing-Contraction Strategy. Wong, C. T. T.; Lam, H. Y.; Song, T.; Chen, G.*; Li, X.* Angew. Chem. Int. Ed. 2013, 125, 10402.  
 

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