The combination of room-temperature phosphorescence (RTP) and covalent organic frameworks (COFs) would give rise to a new class of functional materials with sensing and responsive properties. However, such organic materials have been rarely reported, especially for those with long phosphorescence lifetimes. Here we report the incorporation of RTP emitters into COFs either via chemical decoration or noncovalent doping to achieve ultralong RTP in a COF system. The RTP emitters are designed with small phosphorescence rates and consequently exhibit ultralong phosphorescence lifetimes when nonradiative decay and oxygen quenching are suppressed in COF system. The RTP-COF materials have been found to possess oxygen sensing properties with large response of phosphorescence lifetimes.

Herein we report a Ti(III)-mediated dehydroxylative cross-coupling reaction of allylic alcohols with electron-deficient olefins. This reaction is amenable to various synthetically versatile allylic alcohols, including geraniol and farnesol, providing a general method for dehydroxylative C-C bond formation. We demonstrated the reaction's utility by simplifying the syntheses of eight useful building blocks that are otherwise laborious to prepare.

The berberine bridge enzyme (BBE)-like flavoproteins have attracted continuous attention for their capability to catalyze various oxidative reactions. Here we demonstrate that MitR, a secreted BBE-like enzyme, functions as a special drug-binding efflux protein evolved from quinone reductase. Moreover, this protein provides self-resistance to its hosts toward the DNA-alkylating agent mitomycin C with a distinctive strategy, featured by independently performing drug binding and efflux.

C-H functionalization and dearomatization constitute fundamental transformations of aromatic compounds, which find wide applications in various research areas. However, achieving both transformations from the same substrates with a single catalyst by operating a distinct mechanism remains challenging. Here, we report a photocatalytic strategy to modulate the reaction pathways that can be directed toward either C-H functionalization or dearomatization under redox-neutral or net-reductive conditions, respectively. Two sets of indoles and indolines bearing tertiary alcohols are divergently furnished with good yields and high selectivity. The key to success is the introduction of isoazatruxene ITN-2 as a novel photocatalyst (PC), which outperforms the commonly used PCs. The ready synthesis and high modulability of isoazatruxene type PCs indicate their great application potential. Starting from the same substrates, tunable C-H functionalization and dearomatization have been achieved under the catalysis of a new organic photocatalyst - isoazatruxene ITN-2.

Prof. Qing-Yun Chen left us forever on March 2, 2023, at the age of 94. He will always be remembered for his great scientific contribution to organofluorine chemistry. This article reviews some of his legacy, summarizes his key scientific accomplishments, and is dedicated to the respected scientist, devoted mentor, and approachable person that he was.

Linkage chemistry and functional molecules derived from the stereogenic sulfur(VI) centre have important applications in organic synthesis, bioconjugation, drug discovery, agrochemicals and polymeric materials. However, existing approaches for the preparation of optically active S(VI)-centred compounds heavily rely on synthetic chiral S(IV) pools, and the reported linkers of S(VI) lack stereocontrol. A modular assembly method, involving sequential ligand exchange at the S(VI) centre with precise control of enantioselectivity, is appealing but remains elusive. Here we report an asymmetric three-dimensional sulfur(VI) fluoride exchange (3D-SuFEx) reaction based on thionyl tetrafluoride gas (SOF4). A key step involves the chiral ligand-induced enantioselective defluorinative substitution of iminosulfur oxydifluorides using organolithium reagents. The resulting optically active sulfonimidoyl fluorides allow for further stereospecific fluoride-exchange by various nucleophiles, thereby establishing a modular platform for the asymmetric SuFEx ligation and the divergent synthesis of optically active S(VI) functional molecules. Chirality is an intrinsic property in unsymmetric three-dimensional molecular assembly, contributing to the utility of the corresponding process and the resulting scaffolds. Now, on the sulfur(VI) hub, a three-step sequential ligand-exchange method has been established with precise stereocontrol, enabling the enantioselective synthesis of optically active S(VI) functional molecules.

The mechanism of stereoselective polymerization of styrene catalyzed by rare-earth metal complexes was studied using computational means. Having achieved agreement with experimental results, we found that the noncovalent interaction between the additive alloxybenzene and the polymer chain/monomer was the main factor governing stereoselectivity. The mechanism of stereoselective polymerization of styrene catalyzed by rare-earth metal complexes was studied using computational means.

Despite binuclear Cu active sites present in some biological and heterogeneous catalysts, the development of chiral binuclear copper catalysts is still in its infancy and remains a formidable challenge. A notable example is that the asymmetric propargylic substitution catalyzed by a chiral binuclear Cu complex is still unknown, although some kinds of in -situ -assembled binuclear Cu species have frequently been proposed as active intermediates. Herein, we report a series of binuclear copper catalysts supported by chiral benzo [c] cinnoline dioxazoline frameworks, which demonstrated high efficiency in (dynamic) kinetic resolution of propargylic alcohol derivatives via propargylic substitution. Mechanistic investigations suggested that the binuclear Cu core shows a bifunctional role in coordination with acetylide and allenylidene ligands. These findings shed light onto the long-standing mechanistic ambiguity, providing solid support for the proposal that the binuclear Cu core can be crucial for substrate activation and selectivity control in catalysis.

The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl- extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2, and NCC)-mediated Cl- loading. The CCCs play vital roles in cell volume regulation and ion homeostasis. Gain-of-function or loss-of-function of these ion transporters can cause diseases in many tissues. In recent years, there have been considerable advances in our understanding of CCCs' control mechanisms in cell volume regulations, with many techniques developed in studying the functions and activities of CCCs. Classic approaches to directly measure CCC activity involve assays that measure the transport of potassium substitutes through the CCCs. These techniques include the ammonium pulse technique, radioactive or nonradioactive rubidium ion uptake-assay, and thallium ion-uptake assay. CCCs' activity can also be indirectly observed by measuring g- aminobutyric acid (GABA) activity with patch-clamp electrophysiology and intracellular chloride concentration with sensitive microelectrodes, radiotracer 36Cl-, and fluorescent dyes. Other techniques include directly looking at kinase regulatory sites phosphorylation, flame photometry, 22Na+ uptake assay, structural biology, molecular modeling, and high-throughput drug screening. This review summarizes the role of CCCs in genetic disorders and cell volume regulation, current methods applied in studying CCCs biology, and compounds developed that directly or indirectly target the CCCs for disease treatments. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).