PUBLICATIONS

Zhou L, Bi J, Chang S, Bai Z, Yu J, Wang R, Li Z, Zhang X, Chou JJ* , Pan L*. Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides. Angew Chem Int Ed Engl e202415272. doi: 10.1002/anie.202415272 (2024).

JAMES J. CHOU.CHAPTER 8:RDC for Membrane Proteins.Residual Dipolar Couplings Principles and Applications(ed. L. Yao and B. Vogeli), Royal Society of Chemistry,vol. 31,159-180 (2024).

Tiantian Cai, Rachel Lenoir Capello, Xiong Pi, Hao Wu, James J. Chou. Structural basis of γ-chain family receptor sharing at the membrane level. Science 381(6657):569-576. doi: 10.1126/science.add1219 (2023).

Zhou L, Yang F*, Bai Z, Zhou X, Zhang Z, Li Z, Gong J, Yu J, Pan L, Cao C*, Chou JJ. Self-Assembled L-DNA Linkers for Rapid Construction of Multi-Specific Antibody-Drug Conjugates Library. Angew Chem Int Ed Engl e202302805. doi:10.1002/anie.202302805 (2023).

Pan L, Chou JJ, Fu T. Editorial: Targeting TNF/TNFR signaling pathways. Front Pharmacol. doi:10.3389/fphar.2022.1120954 (2023).

Du G^, Zhao L^, Zheng Y, Belfetmi A, Cai T, Xu B, Heyninck K, Van Den Heede K, Buyse MA, Fontana P, Bowman M, Lin LL, Wu H*, Chou JJ*. Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Res 33(2):131-146. doi:10.1038/s41422-022-00755-2 (2023).

Zhuang X, Wang Z, Fan J, Bai X, Xu Y, Chou JJ, Hou T, Chen S, Pan L. Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance. Nat Commun 13(1):4431, doi:10.1038/s41467-022-32159-6 (2022).

Velarde JJ, Piai A, Lichtenstein IJ, Lynskey NN, Chou JJ, Wessels MR. Structure of the Streptococcus pyogenes NAD+ Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes. J Bacteriol 204(1):e0036621, doi:10.1128/JB.00366-21 (2022).

Wei S, Hu X, Du L, Zhao L, Xue H, Liu C, Chou JJ, Zhong J, Tong Y, Wang S, OuYang B. Inhibitor Development against p7 Channel in Hepatitis C Virus. Molecules 26(5):1350. doi: 10.3390/molecules26051350 (2021).

Lv F, Qi F, Zhang Z, Wen M, Kale J, Piai A, Du L, Wang S, Zhou L, Yang Y, Wu B, Liu Z, Del Rosario J, Pogmore J, Chou JJ, Andrews DW, Lin J, OuYang B. An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane. EMBO J 40(14):e106438, doi:10.15252/embj.2020106438 (2021).

Fu Q, Chou JJ. A Trimeric Hydrophobic Zipper Mediates the Intramembrane Assembly of SARS-CoV-2 Spike. J Am Chem Soc 143(23):8543-8546, doi:10.1021/jacs.1c02394 (2021).

Piai A^, Fu Q^, Sharp AK^, Bighi B, Brown AM*, Chou JJ*. NMR Model of the Entire Membrane-Interacting Region of the HIV-1 Fusion Protein and Its Perturbation of Membrane Morphology. J Am Chem Soc 143(17):6609-6615, doi:10.1021/jacs.1c01762 (2021).

Zhao L, Fu Q, Pan L, Piai A, Chou JJ. The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors. Front Cell Dev Biol 8:569684, doi:10.3389/fcell.2020.569684 (2020).

Piai A^, Fu Q^, Cai Y, Ghantous F, Xiao T, Shaik MM, Peng H, Rits-Volloch S, Chen W, Seaman MS, Chen B*, Chou JJ*. Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Nat Commun 11(1):2317, doi:10.1038/s41467-020-16165-0 (2020).

Yuan Y^, Cao C^, Wen M, Li M, Dong Y, Wu L, Wu J, Cui T, Li D, Chou JJ*, OuYang B*. Structural Characterization of the N-Terminal Domain of the Dictyostelium discoideum Mitochondrial Calcium Uniporter. ACS Omega 5(12):6452-6460, doi:10.1021/acsomega.9b04045 (2020).

Xiao T, Frey G, Fu Q, Lavine CL, Scott DA, Seaman MS, Chou JJ, Chen B. HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat Chem Biol 16(5):529-537, doi:10.1038/s41589-020-0496-y (2020).

Pan L^, Cao C^, Run C, Zhou L, Chou JJ. DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing. Adv Sci (Weinh) 7(2):1900973, doi:10.1002/advs.201900973 (2020).

Chen W, OuYang B, Chou JJ. Critical Effect of the Detergent:Protein Ratio on the Formation of the Hepatitis C Virus p7 Channel. Biochemistry 58(37):3834-3837, doi:10.1021/acs.biochem.9b00636 (2019).

Fu Q, Piai A, Chen W, Xia K, Chou JJ. Structure determination protocol for transmembrane domain oligomers. Nat Protoc 14(8):2483-2520, doi:10.1038/s41596-019-0188-9 (2019).

Chen W, Cai Y, Fu Q, Chen B, Guo J*, Chou JJ*. Unidirectional Presentation of Membrane Proteins in Nanoparticle-Supported Liposomes. Angew Chem Int Ed Engl 58(29):9866-9870, doi:10.1002/anie.201903093 (2019).

Pan L^, Fu TM^, Zhao W^, Zhao L^, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H*, Chou JJ*. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell 176(6):1477-1489.e14, doi:10.1016/j.cell.2019.02.001 (2019).

Chen W, OuYang B, Chou JJ. Chen et al. reply. Nature 562(7727):E19-E20. doi: 10.1038/s41586-018-0562-8 (2018).

Fu Q^, Shaik MM^, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC, Seaman MS, Chen B*, Chou JJ*. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci 115(38):E8892-E8899, doi:10.1073/pnas.1807259115 (2018).

Yang Q, Brüschweiler S, Zhao L, Chou JJ. Reply to 'Concerns with yeast mitochondrial ADP/ATP carrier's integrity in DPC' and 'Dynamics and interactions of AAC3 in DPC are not functionally relevant'. Nat Struct Mol Biol 25(9):749-750. doi: 10.1038/s41594-018-0126-5 (2018).

Chen W, Dev J, Mezhyrova J, Pan L, Piai A, Chou JJ. The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus. Structure 26(4):627-634.e4, doi:10.1016/j.str.2018.02.011 (2018).

Peng L, Zhang F, Shang R, Wang X, Chen J, Chou JJ, Ma J, Wu L, Huang Y. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain. J Biol Chem 293(26):9981-9994, doi: 10.1074/jbc.RA117.000837 (2018).

Yang J, Piai A, Shen HB, Chou JJ. An Exhaustive Search Algorithm to Aid NMR-Based Structure Determination of Rotationally Symmetric Transmembrane Oligomers. Sci Rep 7(1):17373, doi:10.1038/s41598-017-17639-w (2017).

Piai A^, Dev J^, Fu Q, Chou JJ. Stability and Water Accessibility of the Trimeric Membrane Anchors of the HIV-1 Envelope Spikes. J Am Chem Soc 139(51):18432-18435, doi:10.1021/jacs.7b09352 (2017).

Zhao L, Wang S, Zhu Q, Wu B, Liu Z, OuYang B*, Chou JJ*. Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid. Structure 25(9):1371-1379.e3, doi:10.1016/j.str.2017.07.005 (2017).

Cao C, Wang S, Cui T, Su XC*, Chou JJ*. Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter. Proc Natl Acad Sci 114(14):E2846-E2851, doi:10.1073/pnas.1620316114 (2017).

Pan L, Zhao W, Lai J, Ding D, Zhang Q, Yang X, Huang M, Jin S, Xu Y, Zeng S, Chou JJ, Chen S. Sortase A-Generated Highly Potent Anti-CD20-MMAE Conjugates for Efficient Elimination of B-Lineage Lymphomas. Small 13(6), doi:10.1002/smll.201602267 (2017).

Chen B, Chou JJ. Structure of the transmembrane domain of HIV-1 envelope glycoprotein. FEBS J 284(8):1171-1177, doi:10.1111/febs.13954 (2017).

Piai A, Fu Q, Dev J, Chou JJ. Optimal Bicelle Size q for Solution NMR Studies of the Protein Transmembrane Partition. Chemistry 23(6):1361-1367,doi:10.1002/chem.201604206 (2017). 

Zhao L, Wang S, Run C, OuYang B, Chou JJ. Specific Lipid Binding of Membrane Proteins in Detergent Micelles Characterized by NMR and Molecular Dynamics. Biochemistry 55(38):5317-20, doi:10.1021/acs.biochem.6b00836 (2016).

Dev J^, Park D^, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ. Structural basis for membrane anchoring of HIV-1 envelope spike. Science 353(6295):172-175, doi:10.1126/science.aaf7066 (2016).

Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ. Architecture of the mitochondrial calcium uniporter. Nature 533(7602):269-73, doi:10.1038/nature17656 (2016).

Zhao L, Wang S, Du L, Dev J, Zhou L, Liu Z, Chou JJ, OuYang B. Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell 7(4):300-304, doi:10.1007/s13238-016-0256-7 (2016).

Oxenoid K, Chou JJ. A functional NMR for membrane proteins: dynamics, ligand binding, and allosteric modulation. Protein Sci 25(5):959-73, doi:10.1002/pro.2910 (2016).

Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H*, Chou JJ*. Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol Cell 61(4):602-613, doi:10.1016/j.molcel.2016.01.009 (2016).

Williamson JA^, Cho SH^, Ye J, Collet JF, Beckwith JR*, Chou JJ*. Structure and multistate function of the transmembrane electron transporter CcdA. Nat Struct Mol Biol 22(10):809-14, doi:10.1038/nsmb.3099 (2015).

Andreas LB, Reese M, Eddy MT, Gelev V, Ni QZ, Miller EA, Emsley L, Pintacuda G, Chou JJ, Griffin RG. Structure and Mechanism of the Influenza A M218-60 Dimer of Dimers. J Am Chem Soc 137(47):14877-86, doi:10.1021/jacs.5b04802 (2015).

Brüschweiler S, Yang Q, Run C, Chou JJ. Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion. Nat Struct Mol Biol 22(8):636-41, doi:10.1038/nsmb.3059 (2015).

Run C, Yang Q, Liu Z, OuYang B, Chou JJ. Molecular Basis of MgATP Selectivity of the Mitochondrial SCaMC Carrier. Structure 23(8):1394-1403, doi:10.1016/j.str.2015.06.004 (2015).

Chou JJ, Wang JH. Transmembrane signaling: A multiplex problem with converging solutions. Prog Biophys Mol Biol 118(3):87-8, doi:10.1016/j.pbiomolbio.2015.06.006 (2015).

Dev J, Brüschweiler S, Ouyang B, Chou JJ. Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing. J Biomol NMR 61(3-4):369-78, doi:10.1007/s10858-015-9912-0 (2015).

Sounier R, Bellot G, Chou JJ. Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states. Angew Chem Int Ed Engl 54(8):2436-41, doi:10.1002/anie.201408417 (2015).

Andreas LB, Reese M, Eddy MT, Gelev V, Ni QZ, Cala D, Stanek J, Lalli D, Le Marchand T, Bertarello A, Miller EA, Chou JJ, Emsley L, Griffin RG, Pintacuda G. Atom resolution structure of non-crystalline membrane proteins in lipid bilayers by magic-angle spinning nuclear magnetic resonance. FEBS J 282:51 (2015).

Colvin MT, Andreas LB, Chou JJ, Griffin RG. Proton association constants of His37 in the Influenza-A M218-60 dimer-of-dimers. Biochemistry 53(38):5987-94, doi:10.1021/bi5005393 (2014).

Berardi MJ, Chou JJ,. Fatty acid flippase activity of UCP2 is essential for its proton transport in mitochondria. Cell Metab 20(3):541-52, doi:10.1016/j.cmet.2014.07.004 (2014).

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ. Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore. PLoS Pathog 10(8):e1004294 (2014).

Kalita MM, Griffin SDC, Chou JJ, Fischer WB. In Silico Assessment of Bundle Architectures of HCV P7 Protein. Biophysical Journal 106(2):54A-A, doi: 10.1016/j.bpj.2013.11.382 (2014).

Barbet-Massin E, Pell AJ, Retel JS, Andreas LB, Jaudzems K, Franks WT, Nieuwkoop AJ, Hiller M, Higman V, Guerry P, Bertarello A, Knight MJ, Felletti M, Le Marchand T, Kotelovica S, Akopjana I, Tars K, Stoppini M, Bellotti V, Bolognesi M, Ricagno S, Chou JJ, Griffin RG, Oschkinat H, Lesage A, Emsley L, Herrmann T, Pintacuda G. Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning. J Am Chem Soc 136(35):12489-97 (2014).

Yang Q, Brüschweiler S, Chou JJ. A self-sequestered calmodulin-like Ca²⁺ sensor of mitochondrial SCaMC carrier and its implication to Ca²⁺-dependent ATP-Mg/P(i) transport. Structure 22(2):209-17, doi:10.1016/j.str.2013.10.018 (2014).

Yang Q, Brüschweiler S, Chou JJ. Purification, crystallization and preliminary X-ray diffraction of the N-terminal calmodulin-like domain of the human mitochondrial ATP-Mg/Pi carrier SCaMC1. Acta Crystallogr F Struct Biol Commun 70(Pt 1):68-71, doi:10.1107/S2053230X1303241X (2014).

OuYang B, Chou JJ. The minimalist architectures of viroporins and their therapeutic implications. Biochim Biophys Acta 1838(4):1058-67, doi:10.1016/j.bbamem.2013.09.004 (2014).

OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B, Chou JJ. Unusual architecture of the p7 channel from hepatitis C virus. Nature 498(7455):521-5, doi:10.1038/nature12283 (2013).

Bellot G, McClintock MA, Chou JJ, Shih WM. DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc 8(4):755-70, doi:10.1038/nprot.2013.037 (2013).

Oxenoid K, Chou JJ. The present and future of solution NMR in investigating the structure and dynamics of channels and transporters. Curr Opin Struct Biol 23(4):547-54, doi: 10.1016/j.sbi.2013.03.010 (2013).

Andreas LB, Barnes AB, Corzilius B, Chou JJ, Miller EA, Caporini M, Rosay M, Griffin RG. Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A. Biochemistry 52(16):2774-82, doi: 10.1021/bi400150x (2013).

Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol 20(2):135-8, doi: 10.1038/nsmb.2508 (2013).

Chou JJ, Sounier R. Solution nuclear magnetic resonance spectroscopy. Methods Mol Biol 955:495-517, doi:10.1007/978-1-62703-176-9_26 (2013).

Andreas LB, Eddy MT, Chou JJ, Griffin RG. Magic-angle-spinning NMR of the drug resistant S31N M2 proton transporter from influenza A. J Am Chem Soc 134(17):7215-8, doi: 10.1021/ja3003606 (2012).

Pielak RM, Oxenoid K, Chou JJ. Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure 19(11):1655-63, doi: 10.1016/j.str.2011.09.003 (2011).

Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell 147(5):1080-91, doi: 10.1016/j.cell.2011.10.020 (2011).

Berardi MJ, Shih WM, Harrison SC, Chou JJ. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature 476(7358):109-13. doi: 10.1038/nature10257 (2011).

Pielak RM, Chou JJ. Flu channel drug resistance: a tale of two sites. Protein Cell 1(3):246-58, doi: 10.1007/s13238-010-0025-y (2010).

Call ME, Chou JJ. A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer. Structure 18(12):1559-69, doi: 10.1016/j.str.2010.11.002 (2010).

Pielak RM, Chou JJ. Kinetic analysis of the M2 proton conduction of the influenza virus. J Am Chem Soc 132(50):17695-7, doi: 10.1021/ja108458u (2010).

Call ME, Wucherpfennig KW*, Chou JJ*. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol 11(11):1023-9. doi: 10.1038/ni.1943 (2010).

Pielak RM, Chou JJ. Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun 401(1):58-63. doi: 10.1016/j.bbrc.2010.09.008 (2010).

Pielak RM, Chou JJ. Influenza M2 proton channels. Biochimica et Biophysica Acta 401(1):58-63 (2010).

Gagnon E, Xu CQ, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW. Multilayered Control of T Cell Receptor Phosphorylation Response. Cell 142(5):669-71, doi: 10.1016/j.cell.2010.08.019 (2010).

Chou JJ, Schnell JR: Structure and Mechanism of the M2 Channel In Influenza: Molecular Virology , Q. Wang, and Y.J. Tao, eds. (Norwich, UK, Horizon Scientific Press), chapter 6 (2010).

Wang J, Pielak RM, McClintock MA, Chou JJ. Solution structure and functional analysis of the influenza B proton channel. Nat Struct Mol Biol 16(12):1267-71, doi: 10.1038/nsmb.1707 (2009).

Pielak RM, Schnell JR, Chou JJ. Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc Natl Acad Sci U S A 106(18):7379-84, doi: 10.1073/pnas.0902548106 (2009).

Yoon MK, Venkatachalam V, Huang A, Choi BS*, Stultz CM*, Chou JJ*. Residual structure within the disordered C-terminal segment of p21(Waf1/Cip1/Sdi1) and its implications for molecular recognition. Protein Sci 18(2):337-47, doi: 10.1002/pro.34 (2009).

Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ*, Wucherpfennig KW*. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell 135(4):702-13, doi: 10.1016/j.cell.2008.09.044 (2008).

Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC. Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem 283(47):32860-9, doi: 10.1074/jbc.M804916200 (2008).

Shen H, Chou JJ. MemBrain: improving the accuracy of predicting transmembrane helices. PLoS One 3(6):e2399, doi: 10.1371/journal.pone.0002399 (2008).

Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451(7178):591-5, doi: 10.1038/nature06531 (2008).

Oxenoid K, Rice AJ, Chou JJ. Comparing the structure and dynamics of phospholamban pentamer in its unphosphorylated and pseudo-phosphorylated states. Protein Sci 16(9):1977-83. doi: 10.1110/ps.072975107 (2007).

Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC. Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol 371(2):501-13, doi: 10.1016/j.jmb.2007.05.062 (2007).

Douglas SM, Chou JJ*, Shih WM*. DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. Proc Natl Acad Sci U S A 104(16):6644-8, doi: 10.1073/pnas.0700930104 (2007).

Kubat JA, Chou JJ, Rovnyak D. Nonuniform sampling and maximum entropy reconstruction applied to the accurate measurement of residual dipolar couplings. J Magn Reson 186(2):201-11, doi: 10.1016/j.jmr.2007.01.022 (2007).

Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell 127(2):355-68, doi: 10.1016/j.cell.2006.08.044 (2006).

Potluri S, Yan AK, Chou JJ, Donald BR, Bailey-Kellogg C. Structure determination of symmetric homo-oligomers by a complete search of symmetry configuration space, using NMR restraints and van der Waals packing. Proteins 65(1):203-19, doi: 10.1002/prot.21091 (2006).

Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure 14(6):1003-9, doi: 10.1016/j.str.2006.04.007 (2006).

Carothers JM, Davis JH, Chou JJ, Szostak JW. Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA 12(4):567-79. doi: 10.1261/rna.2251306 (2006).

Zhou X, Chou JJ, Wong ST. Protein structure similarity from principle component correlation analysis. BMC Bioinformatics 7:40 (2006).

Schnell JR, Zhou GP, Zweckstetter M, Rigby AC, Chou JJ. Rapid and accurate structure determination of coiled-coil domains using NMR dipolar couplings: application to cGMP-dependent protein kinase Ialpha. Protein Sci 14(9):2421-8, doi: 10.1110/ps.051528905 (2005).

Zweckstetter M, Schnell JR, Chou JJ. Determination of the packing mode of the coiled-coil domain of cGMP-dependent protein kinase Ialpha in solution using charge-predicted dipolar couplings. J Am Chem Soc 127(34):11918-9, doi: 10.1021/ja0534654 (2005).

Oxenoid K, Chou JJ. The structure of phospholamban pentamer reveals a channel-like architecture in membranes. Proc Natl Acad Sci U S A 102(31):10870-5, doi: 10.1073/pnas.0504920102 (2005).

Wang J, Schnell JR, Chou JJ. Amantadine partition and localization in phospholipid membrane: a solution NMR study. Biochem Biophys Res Commun 324(1):212-7, doi: 10.1016/j.bbrc.2004.09.039 (2004).

Chou JJ, Baber JL, Bax A. Characterization of phospholipid mixed micelles by translational diffusion. J Biomol NMR 29(3):299-308, doi: 10.1023/B:JNMR.0000032560.43738.6a (2004).

Chou JJ, Case DA, Bax A. Insights into the mobility of methyl-bearing side chains in proteins from (3)J(CC) and (3)J(CN) couplings. J Am Chem Soc 125(29):8959-66, doi: 10.1021/ja029972s (2003).

Chou JJ, Kaufman JD, Stahl SJ, Wingfield PT, Bax A. Micelle-induced curvature in a water-insoluble HIV-1 Env peptide revealed by NMR dipolar coupling measurement in stretched polyacrylamide gel. J Am Chem Soc 124(11):2450-1, doi: 10.1021/ja017875d (2002).

Bax A, Chou JJ, Ramirez B. Liquid Crystalline Samples: Application to Macromolecular Structure Determination. Encyclopedia of Nuclear Magnetic Resonance (D. M. Grant and R. K. Harris, eds), 9, 401-412 (2001).

Chou JJ, Gaemers S, Howder B, Louis JM, Bax A. A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micelles. J Biomol NMR 21(4):377-82, doi: 10.1023/a:1013336502594

(2001).

Chou JJ, Li S, Klee CB, Bax A. Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains. Nat Struct Biol 8(11):990-7, doi: 10.1038/nsb1101-990 (2001)

Chou JJ, Bax A. Protein side-chain rotamers from dipolar couplings in a liquid crystalline phase. J Am Chem Soc 123(16):3844-5, doi: 10.1021/ja015660y (2001).

Chou JJ, Li S, Bax A. Study of conformational rearrangement and refinement of structural homology models by the use of heteronuclear dipolar couplings. J Biomol NMR 18(3):217-27, doi: 10.1023/a:1026563923774 (2000).

Chou JJ, Delaglio F, Bax A. Measurement of one-bond 15N-13C' dipolar couplings in medium sized proteins. J Biomol NMR 18(2):101-5, doi: 10.1023/a:1008358318863 (2000).

Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell 99(7):747-55, doi: 10.1016/s0092-8674(00)81672-4 (1999).

Zhou P, Chou JJ, Olea RS, Yuan J, Wagner G. Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction, Proc Natl Acad Sci U S A 96:11265-70 (1999).

Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell 96(5):615-24, doi: 10.1016/s0092-8674(00)80572-3 (1999).

Chou JJ, Matsuo H, Duan H, Wagner G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94(2):171-80, doi: 10.1016/s0092-8674(00)81417-8 (1998).

Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Thomas RC, Aristoff PA, Tarpley WG, et al. Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E. Biochem Pharmacol 47(11):2017-28, doi: 10.1016/0006-2952(94)90077-9 (1994).

Chou JJ. A formulation for correlating properties of peptides and its application to predicting human immunodeficiency virus protease-cleavable sites in proteins. Biopolymers 33(9):1405-14, doi: 10.1002/bip.360330910 (1993).

Althaus IW, Gonzales AJ, Chou JJ, Romero DL, Deibel MR, Chou KC, Kezdy FJ, Resnick L, Busso ME, So AG, et al. The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase. J Biol Chem 268(20):14875-80 (1993).

Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Palmer JR, Thomas RC, Aristoff PA, et al. Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E. Biochemistry 32(26):6548-54, doi: 10.1021/bi00077a008 (1993).

Chou JJ. Predicting cleavability of peptide sequences by HIV protease via correlation-angle approach. J Protein Chem 268(9):6119-24 (1993).

Chou JJ, Zhang CT. A joint prediction of the folding types of 1490 human proteins from their genetic codons. J Theor Biol 161(2):251-62, doi: 10.1006/jtbi.1993.1053 (1993).