Understanding IL-2R family receptor sharing at the membrane level; Cai et al, Science 2023
Specific structure and autoinhibitory function of preligand clusters of TRAIL receptor2
Active role of receptor transmembrane domain in driving receptor clustering and activation
Cross membrane Conformational Coupling of HIV-1 spike protein
Welcome to the James Lab!
Our research program integrates structural biology, cell biology, and nanotechnology to fill the long-standing knowledge gaps in receptor biology such as receptor preligand conformation, receptor antoinhibition mechanism, and higher-order receptor clustering important for activation and regulation.